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Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters.

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorPICART, Léo
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMAZEL, Vincent
IDREF: 113057954
dc.contributor.authorMOULIN, Aline
dc.contributor.authorBOURGEAUX, Vanessa
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorTCHORELOFF, Pierre
IDREF: 069233624
dc.date.accessioned2021-12-21T10:22:22Z
dc.date.available2021-12-21T10:22:22Z
dc.date.issued2022-01-25
dc.identifier.issn1873-3476en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124289
dc.description.abstractEnPress-coated tablets are a high-interest technology in chronopharmaceutics, for modified release applications. As for any kind of tablet, the test of the mechanical resistance is of primary importance at the industrial level during both the development and production steps. For this purpose, the diametral compression test is commonly used in the industry for press-coated tablets. Nevertheless, the result of this test can be much more complex compared to the case of single layer tablets. This work aims to study the applicability of this test to press-coated tablets. Diametral compression tests were performed on press-coated tablets obtained with different products (shell/core), shell sizes and compaction pressures. Four types of breaking profiles were found: total diametral, shell diametral, around the core and laminated depending on the process parameters/products used to obtain the tablet. Digital image correlation was used in order to understand the breaking patterns especially in terms of failure initiation and propagation. The kind of breaking pattern obtained is dependent on the final structure of the tablet in terms of density distribution and thus of elastic properties. To confirm the findings, numerical simulations by the finite element method was used to visualize the stress distribution inside the tablet and confirm the influence of the process parameters. The multiple failure profiles obtained imply that the output value of the diametral compression test applied to press-coated tablets should be taken with caution.
dc.language.isoENen_US
dc.subject.enBreakage
dc.subject.enDiametral compression test
dc.subject.enMechanical properties
dc.subject.enPress-coating
dc.subject.enTablet
dc.title.enBreaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters.
dc.title.alternativeInt J Pharmen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ijpharm.2021.121371en_US
dc.subject.halSciences de l'ingénieur [physics]/Autreen_US
dc.identifier.pubmed34902454en_US
bordeaux.journalInternational journal of pharmaceuticsen_US
bordeaux.page121371en_US
bordeaux.volume612en_US
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionArts et Métiersen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03498861
hal.version1
hal.date.transferred2021-12-21T10:22:24Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.date=2022-01-25&rft.volume=612&rft.spage=121371&rft.epage=121371&rft.eissn=1873-3476&rft.issn=1873-3476&rft.au=PICART,%20L%C3%A9o&MAZEL,%20Vincent&MOULIN,%20Aline&BOURGEAUX,%20Vanessa&TCHORELOFF,%20Pierre&rft.genre=article


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