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dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorVÉRIT, Isabel
dc.contributor.authorGEMINI, Laura
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFRICAIN, Jean-Christophe
ORCID: 0000-0001-7855-6437
dc.contributor.authorKLING, Rainer
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorRIGOTHIER, Claire
dc.date.accessioned2021-12-21T09:10:30Z
dc.date.available2021-12-21T09:10:30Z
dc.date.issued2021-02-01
dc.identifier.issn1435-604Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124244
dc.description.abstractEnCell oxygenation and nutrition are crucial for the viability of tissue-engineered constructs, and different alternatives are currently being developed to achieve an adequate vascularisation of the engineered tissue. One of the alternatives is the generation of channel-like patterns in a bioconstruct. Here, the formation of full-formed channels inside hydrogels by laser-induced cavitation was investigated. A near-infrared, femtosecond laser beam focused with a high numerical aperture was employed to obtain intra-volume modifications of a block of gelatine hydrogel. Characterisation of the laser-processed gelatine was carried out by optical microscopy and epifluorescence microscopy right after and 24 h after the laser process. Rheology analyses on the unprocessed gelatine blocks were conducted to better understand the cavitation mechanism taking place during the intense laser interaction. Different cavitation patterns were observed at varying dose values by changing the repetition rate and the overlap between successive pulses while keeping the laser fluence and the number of passes fixed. This way, cavitation bubble features and behaviour can be controlled to optimise the formation of intra-volume channels in the gelatine volume. Results showed that the generation of fully formed channels was linked to the formation of large non-spherical cavitation bubbles during the laser interaction at high dose and low repetition rates. In conclusion, the formation of fully formed channels was made possible with a near-infrared, femtosecond laser beam strongly focused inside gelatine hydrogel blocks through laser-induced cavitation at high dose and low repetition rates.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enDose-Response Relationship
dc.subject.enRadiation
dc.subject.enGelatin
dc.subject.enHydrogels
dc.subject.enLasers
dc.subject.enRheology
dc.subject.enSwine
dc.subject.enTime Factors
dc.subject.enViscosity
dc.subject.enFemtosecond laser-gelatine interaction
dc.subject.enLaser-induced cavitation
dc.subject.enLaser-induced intravolumique channels
dc.subject.enMicrovascularisation
dc.title.enIntra-volume processing of gelatine hydrogel by femtosecond laser-induced cavitation.
dc.title.alternativeLasers Med Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10103-020-03081-4en_US
dc.subject.halSciences du Vivant [q-bio]/Biotechnologiesen_US
dc.identifier.pubmed32594349en_US
bordeaux.journalLasers in Medical Scienceen_US
bordeaux.page197-206en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - UMR_S 1026en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-02889674
hal.version1
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Lasers%20in%20Medical%20Science&rft.date=2021-02-01&rft.volume=36&rft.issue=1&rft.spage=197-206&rft.epage=197-206&rft.eissn=1435-604X&rft.issn=1435-604X&rft.au=V%C3%89RIT,%20Isabel&GEMINI,%20Laura&FRICAIN,%20Jean-Christophe&KLING,%20Rainer&RIGOTHIER,%20Claire&rft.genre=article


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