The risk of dementia in patients using psychotropic drugs: Antidepressants, mood stabilizers or antipsychotics
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DAUBECH-TOURNIER, Marie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PAMBRUN, Elodie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MAUMUS-ROBERT, Sandy | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PARIENTE, Antoine
IDREF: 13395711X | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | VERDOUX, Helene | |
| dc.date.accessioned | 2021-11-30T16:25:38Z | |
| dc.date.available | 2021-11-30T16:25:38Z | |
| dc.date.issued | 2022-01 | |
| dc.identifier.issn | 1600-0447 (Electronic) 0001-690X (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123948 | |
| dc.description.abstractEn | OBJECTIVE: The risk of dementia associated with the use of psychotropic drugs is not fully understood. A nested case-control study was carried out to assess the risk of dementia broadly defined or Alzheimer's disease associated with antidepressants, mood stabilizers or antipsychotics. METHODS: A cohort was formed from healthcare claim databases including all patients aged 50 and over with a first dispensing of the psychotropic drugs concerned between 2006 and 2017. Patients who developed dementia over the study period were considered as cases. The association between drug exposure prior to a five-year lag time and diagnosis of dementia was assessed by conditional logistic regression models. RESULTS: No association was found between dementia, either broadly defined or Alzheimer disease, and antidepressant or mood stabilizers. Findings were conflicting with regard to antipsychotics. First- and second-generation antipsychotics (FGA and SGA) were not associated with Alzheimer disease. SGA treatments of more than 3 months were associated with a higher risk of dementia broadly defined than no use of antipsychotics (Odds ratio [OR] 2.00; 95%CI 1.06-3.79; p = 0.03). In a sensitivity analysis using a lag time of 3 years, ever use of SGA and SGA treatments of more than 3 months were associated with a higher risk of dementia broadly defined than no use of antipsychotics (OR 1.71; 1.10-2.67; p = 0.02 and OR 1.84; 1.03-3.32; p = 0.04, respectively). CONCLUSION: The association between antipsychotics and dementia should be further investigated to establish patients, specific drugs, and patterns of treatment at risk. Prescribers should remain cautious when prescribing them. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Alzheimer disease | |
| dc.subject.en | Antidepressant | |
| dc.subject.en | Antipsychotic | |
| dc.subject.en | Dementia | |
| dc.subject.en | Mood stabilizer | |
| dc.title.en | The risk of dementia in patients using psychotropic drugs: Antidepressants, mood stabilizers or antipsychotics | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/acps.13380 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34689322 | en_US |
| bordeaux.journal | Acta Psychiatrica Scandinavica | en_US |
| bordeaux.page | 56-66 | |
| bordeaux.volume | 145 | |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | pharmacoEpi-Drugs | en_US |
| bordeaux.team | AHEAD_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03457842 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-11-30T16:25:50Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20Psychiatrica%20Scandinavica&rft.date=2022-01&rft.volume=145&rft.issue=1&rft.spage=56-66&rft.epage=56-66&rft.eissn=1600-0447%20(Electronic)%200001-690X%20(Linking)&rft.issn=1600-0447%20(Electronic)%200001-690X%20(Linking)&rft.au=DAUBECH-TOURNIER,%20Marie&PAMBRUN,%20Elodie&MAUMUS-ROBERT,%20Sandy&PARIENTE,%20Antoine&VERDOUX,%20Helene&rft.genre=article |
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