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Associations Between Maternal Depression, Antidepressant Use During Pregnancy, and Adverse Pregnancy Outcomes: An Individual Participant Data Meta-analysis

dc.rights.licenseopenen_US
dc.contributor.authorVLENTERIE, Richelle
dc.contributor.authorVAN GELDER, Marleen M. H. J.
dc.contributor.authorANDERSON, H. Ross
dc.contributor.authorANDERSSON, Liselott
dc.contributor.authorBROEKMAN, Birit F. P.
dc.contributor.authorDUBNOV-RAZ, Gal
dc.contributor.authorEL MARROUN, Hanan
dc.contributor.authorFERREIRA, Ema
dc.contributor.authorFRANSSON, Emma
dc.contributor.authorVAN DER HEIJDEN, Frank M. M. A.
dc.contributor.authorHOLZMAN, Claudia B.
dc.contributor.authorKIM, J. Jo
dc.contributor.authorKHASHAN, Ali S.
dc.contributor.authorKIRKWOOD, Betty R.
dc.contributor.authorKUIJPERS, Harold J. H.
dc.contributor.authorLAHTI-PULKKINEN, Marius
dc.contributor.authorMASON, Dan
dc.contributor.authorMISRA, Dawn
dc.contributor.authorNIEMI, Maria
dc.contributor.authorNORDENG, Hedvig M. E.
dc.contributor.authorPEACOCK, Janet L.
dc.contributor.authorPICKETT, Kate E.
dc.contributor.authorPRADY, Stephanie L.
dc.contributor.authorPREMJI, Shahirose S.
dc.contributor.authorRAIKKONEN, Katri
dc.contributor.authorRUBERTSSON, Christine
dc.contributor.authorSAHINGOZ, Mine
dc.contributor.authorSHAIKH, Kiran
dc.contributor.authorSILVER, Richard K.
dc.contributor.authorSLAUGHTER-ACEY, Jaime
dc.contributor.authorSOREMEKUN, Seyi
dc.contributor.authorSTEIN, Dan J.
dc.contributor.authorSUNDSTROM-POROMAA, Inger
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSUTTER-DALLAY, Anne-Laure
dc.contributor.authorTIEMEIER, Henning
dc.contributor.authorUGUZ, Faruk
dc.contributor.authorVARELA, Pinelopi
dc.contributor.authorVRIJKOTTE, Tanja G. M.
dc.contributor.authorWINTERFELD, Ursula
dc.contributor.authorZAR, Heather J.
dc.contributor.authorZERVAS, Iannis M.
dc.contributor.authorPRINS, Judith B.
dc.contributor.authorPOP-PURCELEANU, Monica
dc.contributor.authorROELEVELD, Nel
dc.date.accessioned2021-11-30T16:04:32Z
dc.date.available2021-11-30T16:04:32Z
dc.date.issued2021-10-01
dc.identifier.issn1873-233X (Electronic) 0029-7844 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123947
dc.description.abstractEnOBJECTIVE: To evaluate the associations of depressive symptoms and antidepressant use during pregnancy with the risks of preterm birth, low birth weight, small for gestational age (SGA), and low Apgar scores. DATA SOURCES: MEDLINE, EMBASE, ClinicalTrials.gov, and PsycINFO up to June 2016. METHODS OF STUDY SELECTION: Data were sought from studies examining associations of depression, depressive symptoms, or use of antidepressants during pregnancy with gestational age, birth weight, SGA, or Apgar scores. Authors shared the raw data of their studies for incorporation into this individual participant data meta-analysis. TABULATION, INTEGRATION, AND RESULTS: We performed one-stage random-effects meta-analyses to estimate odds ratios (ORs) with 95% CIs. The 215 eligible articles resulted in 402,375 women derived from 27 study databases. Increased risks were observed for preterm birth among women with a clinical diagnosis of depression during pregnancy irrespective of antidepressant use (OR 1.6, 95% CI 1.2-2.1) and among women with depression who did not use antidepressants (OR 2.2, 95% CI 1.7-3.0), as well as for low Apgar scores in the former (OR 1.5, 95% CI 1.3-1.7), but not the latter group. Selective serotonin reuptake inhibitor (SSRI) use was associated with preterm birth among women who used antidepressants with or without restriction to women with depressive symptoms or a diagnosis of depression (OR 1.6, 95% CI 1.0-2.5 and OR 1.9, 95% CI 1.2-2.8, respectively), as well as with low Apgar scores among women in the latter group (OR 1.7, 95% CI 1.1-2.8). CONCLUSION: Depressive symptoms or a clinical diagnosis of depression during pregnancy are associated with preterm birth and low Apgar scores, even without exposure to antidepressants. However, SSRIs may be independently associated with preterm birth and low Apgar scores. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42016035711.
dc.language.isoENen_US
dc.title.enAssociations Between Maternal Depression, Antidepressant Use During Pregnancy, and Adverse Pregnancy Outcomes: An Individual Participant Data Meta-analysis
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/aog.0000000000004538en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34623076en_US
bordeaux.journalObstetrics and Gynecologyen_US
bordeaux.page633-646en_US
bordeaux.volume138en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03457738
hal.version1
hal.date.transferred2021-11-30T16:04:48Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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