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Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

dc.rights.licenseopenen_US
dc.contributor.authorMIN, Josine L.
dc.contributor.authorHEMANI, Gibran
dc.contributor.authorHANNON, Eilis
dc.contributor.authorDEKKERS, Koen F.
dc.contributor.authorCASTILLO-FERNANDEZ, Juan
dc.contributor.authorLUIJK, Rene
dc.contributor.authorCARNERO-MONTORO, Elena
dc.contributor.authorLAWSON, Daniel J.
dc.contributor.authorBURROWS, Kimberley
dc.contributor.authorSUDERMAN, Matthew
dc.contributor.authorBRETHERICK, Andrew D.
dc.contributor.authorRICHARDSON, Tom G.
dc.contributor.authorKLUGHAMMER, Johanna
dc.contributor.authorIOTCHKOVA, Valentina
dc.contributor.authorSHARP, Gemma
dc.contributor.authorAL KHLEIFAT, Ahmad
dc.contributor.authorSHATUNOV, Aleksey
dc.contributor.authorIACOANGELI, Alfredo
dc.contributor.authorMCARDLE, Wendy L.
dc.contributor.authorHO, Karen M.
dc.contributor.authorKUMAR, Ashish
dc.contributor.authorSODERHALL, Cilla
dc.contributor.authorSORIANO-TARRAGA, Carolina
dc.contributor.authorGIRALT-STEINHAUER, Eva
dc.contributor.authorKAZMI, Nabila
dc.contributor.authorMASON, Dan
dc.contributor.authorMCRAE, Allan F.
dc.contributor.authorCORCORAN, David L.
dc.contributor.authorSUGDEN, Karen
dc.contributor.authorKASELA, Silva
dc.contributor.authorCARDONA, Alexia
dc.contributor.authorDAY, Felix R.
dc.contributor.authorCUGLIARI, Giovanni
dc.contributor.authorVIBERTI, Clara
dc.contributor.authorGUARRERA, Simonetta
dc.contributor.authorLERRO, Michael
dc.contributor.authorGUPTA, Richa
dc.contributor.authorBOLLEPALLI, Sailalitha
dc.contributor.authorMANDAVIYA, Pooja
dc.contributor.authorZENG, Yanni
dc.contributor.authorCLARKE, Toni Kim
dc.contributor.authorWALKER, Rosie M.
dc.contributor.authorSCHMOLL, Vanessa
dc.contributor.authorCZAMARA, Darina
dc.contributor.authorRUIZ-ARENAS, Carlos
dc.contributor.authorREZWAN, Faisal I.
dc.contributor.authorMARIONI, Riccardo E.
dc.contributor.authorLIN, Tian
dc.contributor.authorAWALOFF, Yvonne
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGERMAIN, Marine
dc.contributor.authorAISSI, Dylan
dc.contributor.authorZWAMBORN, Ramona
dc.contributor.authorVAN EIJK, Kristel
dc.contributor.authorDEKKER, Annelot
dc.contributor.authorVAN DONGEN, Jenny
dc.contributor.authorHOTTENGA, Jouke Jan
dc.contributor.authorWILLEMSEN, Gonneke
dc.contributor.authorXU, Cheng Jian
dc.contributor.authorBARTUREN, Guillermo
dc.contributor.authorCATALA-MOLL, Francesc
dc.contributor.authorKERICK, Martin
dc.contributor.authorWANG, Carol
dc.contributor.authorMELTON, Phillip
dc.contributor.authorELLIOTT, Hannah R.
dc.contributor.authorSHIN, Jean
dc.contributor.authorBERNARD, Manon
dc.contributor.authorYET, Idil
dc.contributor.authorSMART, Melissa
dc.contributor.authorGORRIE-STONE, Tyler
dc.contributor.authorCONSORTIUM, Bios
dc.contributor.authorSHAW, Chris
dc.contributor.authorAL CHALABI, Ammar
dc.contributor.authorRING, Susan M.
dc.contributor.authorPERSHAGEN, Goran
dc.contributor.authorMELEN, Erik
dc.contributor.authorJIMENEZ-CONDE, Jordi
dc.contributor.authorROQUER, Jaume
dc.contributor.authorLAWLOR, Deborah A.
dc.contributor.authorWRIGHT, John
dc.contributor.authorMARTIN, Nicholas G.
dc.contributor.authorMONTGOMERY, Grant W.
dc.contributor.authorMOFFITT, Terrie E.
dc.contributor.authorPOULTON, Richie
dc.contributor.authorESKO, Tonu
dc.contributor.authorMILANI, Lili
dc.contributor.authorMETSPALU, Andres
dc.contributor.authorPERRY, John R. B.
dc.contributor.authorONG, Ken K.
dc.contributor.authorWAREHAM, Nicholas J.
dc.contributor.authorMATULLO, Giuseppe
dc.contributor.authorSACERDOTE, Carlotta
dc.contributor.authorPANICO, Salvatore
dc.contributor.authorCASPI, Avshalom
dc.contributor.authorARSENEAULT, Louise
dc.contributor.authorGAGNON, France
dc.contributor.authorOLLIKAINEN, Miina
dc.contributor.authorKAPRIO, Jaakko
dc.contributor.authorFELIX, Janine F.
dc.contributor.authorRIVADENEIRA, Fernando
dc.contributor.authorTIEMEIER, Henning
dc.contributor.authorVAN IJZENDOORN, Marinus H.
dc.contributor.authorUITTERLINDEN, Andre G.
dc.contributor.authorJADDOE, Vincent W. V.
dc.contributor.authorHALEY, Chris
dc.contributor.authorMCINTOSH, Andrew M.
dc.contributor.authorEVANS, Kathryn L.
dc.contributor.authorMURRAY, Alison
dc.contributor.authorRAIKKONEN, Katri
dc.contributor.authorLAHTI, Jari
dc.contributor.authorNOHR, Ellen A.
dc.contributor.authorSORENSEN, Thorkild I. A.
dc.contributor.authorHANSEN, Torben
dc.contributor.authorMORGEN, Camilla S.
dc.contributor.authorBINDER, Elisabeth B.
dc.contributor.authorLUCAE, Susanne
dc.contributor.authorGONZALEZ, Juan Ramon
dc.contributor.authorBUSTAMANTE, Mariona
dc.contributor.authorSUNYER, Jordi
dc.contributor.authorHOLLOWAY, John W.
dc.contributor.authorKARMAUS, Wilfried
dc.contributor.authorZHANG, Hongmei
dc.contributor.authorDEARY, Ian J.
dc.contributor.authorWRAY, Naomi R.
dc.contributor.authorSTARR, John M.
dc.contributor.authorBEEKMAN, Marian
dc.contributor.authorVAN HEEMST, Diana
dc.contributor.authorSLAGBOOM, P. Eline
dc.contributor.authorMORANGE, Pierre Emmanuel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorVELDINK, Jan H.
dc.contributor.authorDAVIES, Gareth E.
dc.contributor.authorDE GEUS, Eco J. C.
dc.contributor.authorBOOMSMA, Dorret I.
dc.contributor.authorVONK, Judith M.
dc.contributor.authorBRUNEKREEF, Bert
dc.contributor.authorKOPPELMAN, Gerard H.
dc.contributor.authorALARCON-RIQUELME, Marta E.
dc.contributor.authorHUANG, Rae Chi
dc.contributor.authorPENNELL, Craig E.
dc.contributor.authorVAN MEURS, Joyce
dc.contributor.authorIKRAM, M. Arfan
dc.contributor.authorHUGHES, Alun D.
dc.contributor.authorTILLIN, Therese
dc.contributor.authorCHATURVEDI, Nish
dc.contributor.authorPAUSOVA, Zdenka
dc.contributor.authorPAUS, Tomas
dc.contributor.authorSPECTOR, Timothy D.
dc.contributor.authorKUMARI, Meena
dc.contributor.authorSCHALKWYK, Leonard C.
dc.contributor.authorVISSCHER, Peter M.
dc.contributor.authorDAVEY SMITH, George
dc.contributor.authorBOCK, Christoph
dc.contributor.authorGAUNT, Tom R.
dc.contributor.authorBELL, Jordana T.
dc.contributor.authorHEIJMANS, Bastiaan T.
dc.contributor.authorMILL, Jonathan
dc.contributor.authorRELTON, Caroline L.
dc.date.accessioned2021-11-22T08:29:06Z
dc.date.available2021-11-22T08:29:06Z
dc.date.issued2021-09
dc.identifier.issn1061-4036en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123888
dc.description.abstractEnCharacterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a minority of cases do these associations reflect causal relationships from DNAm to trait or vice versa, indicating a more complex genotype-phenotype map than previously anticipated.
dc.language.isoENen_US
dc.title.enGenomic and phenotypic insights from an atlas of genetic effects on DNA methylation
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-021-00923-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34493871en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page1311-1321en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03438928
hal.version1
hal.date.transferred2021-11-22T08:29:21Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Genetics&rft.date=2021-09&rft.volume=53&rft.issue=9&rft.spage=1311-1321&rft.epage=1311-1321&rft.eissn=1061-4036&rft.issn=1061-4036&rft.au=MIN,%20Josine%20L.&HEMANI,%20Gibran&HANNON,%20Eilis&DEKKERS,%20Koen%20F.&CASTILLO-FERNANDEZ,%20Juan&rft.genre=article


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