How Selection Over Time Contributes to the Inconsistency of the Association between Sex/Gender and Cognitive Decline across Cognitive Aging Cohorts
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ROUANET, Anais
IDREF: 198306717 | |
| dc.contributor.author | AVILA-RIEGER, Justina | |
| dc.contributor.author | DUGRAVOT, Aline | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LESPINASSE, Jeremie | |
| dc.contributor.author | STUCKWISCH, Rachel | |
| dc.contributor.author | MERRICK, Richard | |
| dc.contributor.author | ANDERSON, Emma | |
| dc.contributor.author | LONG, Leann | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | JACQMIN-GADDA, Helene | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DUFOUIL, Carole | |
| dc.contributor.author | JUDD, Suzanne | |
| dc.contributor.author | MANLY, Jennifer | |
| dc.contributor.author | SABIA, Severine | |
| dc.contributor.author | GROSS, Alden | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile | |
| dc.date.accessioned | 2021-11-15T11:03:49Z | |
| dc.date.available | 2021-11-15T11:03:49Z | |
| dc.date.issued | 2021-09-14 | |
| dc.identifier.issn | 1476-6256 (Electronic) 0002-9262 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123798 | |
| dc.description.abstractEn | The sex/gender and aging-related cognitive decline association remains poorly understood due to inconsistencies in findings. Such heterogeneity could be attributable to the cognitive functions studied and study population characteristics, but also to a differential selection by drop-out and death between men and women. This work aims to evaluate the impact of selection by drop-out and death on the association between sex/gender and cognitive decline. We first compared the most frequently used statistical methods for longitudinal data, targeting either population estimands (marginal models estimated by Generalized Estimating Equations) or subject-specific estimands (mixed/joint models estimated by likelihood maximization) on eight aging studies: six population-based (ACTIVE(1996-2009), Paquid(1988-2014), REGARDS(2003-2016), 3-City(1999-2016), WHICAP(1992-2017), Whitehall II(2007-2016)) and two clinic-based (ADNI(2004-2017), MEMENTO(2011-2016)) studies. We illustrated the differences in the estimands of the sex/gender association with cognitive decline in selected examples and highlighted the critical role of differential selection by drop-out and death. By using the same estimand, we then contrasted the sex/gender association across cohorts and cognitive measures suggesting residual differential sex/gender association depending on the targeted cognitive measure (memory or animal fluency) and the initial cohort selection. We recommend focusing on subject-specific estimands in the alive population for assessing sex/gender differences while handling differential selection over time. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Aging cohorts | |
| dc.subject.en | Cognition | |
| dc.subject.en | Death | |
| dc.subject.en | Drop-out | |
| dc.subject.en | Longitudinal models | |
| dc.subject.en | Selection | |
| dc.subject.en | Sex/gender | |
| dc.title.en | How Selection Over Time Contributes to the Inconsistency of the Association between Sex/Gender and Cognitive Decline across Cognitive Aging Cohorts | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/aje/kwab227 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34521111 | en_US |
| bordeaux.journal | American Journal of Epidemiology | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.team | VINTAGE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Epidemiology&rft.date=2021-09-14&rft.eissn=1476-6256%20(Electronic)%200002-9262%20(Linking)&rft.issn=1476-6256%20(Electronic)%200002-9262%20(Linking)&rft.au=ROUANET,%20Anais&AVILA-RIEGER,%20Justina&DUGRAVOT,%20Aline&LESPINASSE,%20Jeremie&STUCKWISCH,%20Rachel&rft.genre=article |
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