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Urea based foldamers
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | YOO, Sung Hyun | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LI, Bo | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | DOLAIN, Christel | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | PASCO, Morgane
IDREF: 152520791 | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GUICHARD, Gilles
IDREF: 084339268 | |
| dc.date.accessioned | 2021-11-15T07:26:34Z | |
| dc.date.available | 2021-11-15T07:26:34Z | |
| dc.date.issued | 2021-06-04 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123793 | |
| dc.description.abstractEn | N,N'-linked oligoureas are a class of enantiopure, sequence-defined peptidomimetic oligomers without amino acids that form well-defined and predictable helical structures akin to the peptide α-helix. Oligourea-based foldamers combine a number of features-such as synthetic accessibility, sequence modularity, and folding fidelity-that bode well for their use in a range of applications from medicinal chemistry to catalysis. Moreover, it was recently recognized that this synthetic helical backbone can be combined with regular peptides to generate helically folded peptide-oligourea hybrids that display additional features in terms of helix mimicry and protein-surface recognition properties. Here we provide detailed protocols for the preparation of requested monomers and for the synthesis and purification of homo-oligoureas and peptide-oligourea hybrids. | |
| dc.description.sponsorship | Hélices chimériques aux propriétés innovantes pour l'inhibition des interactions protéine-protéine - ANR-15-CE07-0010 | en_US |
| dc.description.sponsorship | Mimétisme et ingénierie d'enzymes artificielles à l'aide de foldamères - ANR-17-CE07-0020 | en_US |
| dc.language.iso | EN | en_US |
| dc.source.title | Methods in Enzymology Volume 656 | en_US |
| dc.subject.en | Models | |
| dc.subject.en | Molecular | |
| dc.subject.en | Peptides | |
| dc.subject.en | Peptidomimetics | |
| dc.subject.en | Protein Conformation | |
| dc.subject.en | alpha-Helical | |
| dc.subject.en | Urea | |
| dc.title.en | Urea based foldamers | |
| dc.title.alternative | Methods Enzymol | en_US |
| dc.type | Chapitre d'ouvrage | en_US |
| dc.identifier.doi | 10.1016/bs.mie.2021.04.019 | en_US |
| dc.subject.hal | Chimie | en_US |
| dc.identifier.pubmed | 34325800 | en_US |
| bordeaux.page | 59-92 | en_US |
| bordeaux.volume | 656 | en_US |
| bordeaux.hal.laboratories | UMR 5248 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03428128 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-11-15T07:26:41Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Methods%20in%20Enzymology%20Volume%20656&rft.date=2021-06-04&rft.volume=656&rft.spage=59-92&rft.epage=59-92&rft.au=YOO,%20Sung%20Hyun&LI,%20Bo&DOLAIN,%20Christel&PASCO,%20Morgane&GUICHARD,%20Gilles&rft.genre=unknown |
