Cognitive decline as an outcome and marker of progression toward dementia, in early preventive trials
| dc.rights.license | open | en_US |
| dc.contributor.author | MURA, Thibault | |
| dc.contributor.author | COLEY, Nicola | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AMIEVA, Helene | |
| dc.contributor.author | BERR, Claudine | |
| dc.contributor.author | GABELLE, Audrey | |
| dc.contributor.author | OUSSET, Pierre-Jean | |
| dc.contributor.author | VELLAS, Bruno | |
| dc.contributor.author | ANDRIEU, Sandrine | |
| dc.contributor.author | GUIDAGE, D. S. A. Study Group | |
| dc.date.accessioned | 2021-11-08T13:44:23Z | |
| dc.date.available | 2021-11-08T13:44:23Z | |
| dc.date.issued | 2021-09-05 | |
| dc.identifier.issn | 1552-5279 (Electronic) 1552-5260 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123775 | |
| dc.description.abstractEn | INTRODUCTION: Recent Food and Drug Administration guidance endorses cognitive assessment as a possible primary endpoint for early trials for Alzheimer's disease but emphasizes the need for certainty regarding the relationship with progression to dementia. METHODS: We compared the validity of the 2-year change (Y0-Y2) of 11 markers of neuropsychological and functional abilities for the prediction of incident dementia over the following 3 years (Y2-Y5), in 860 subjects aged 70 years or older, who consulted for memory loss and were included in the "GuidAge" prevention trial. RESULTS: The Free and Cued Selective Reminding Test-Free Recall (FCSRT-FR) score showed the most predictive 2-year change (area under the curve = 0.72 95% confidence interval = 0.64;0.81). Changes in other subscores of the FCSRT, verbal fluencies tasks, and composite cognitive score were also significantly predictive. Conversely, 2-year change of Mini-Mental State Examination, Trail Making test (TMT)-A, TMT-B, Clinical Dementia Rating Sum of Boxes, and Instrumental Activities of Daily Living scores did not significantly predict occurrence of dementia. CONCLUSION: The FCSRT, the Fluency Task, and the composite cognitive score appear to be good cognitive markers of progression toward dementia in early prevention trials. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Cognition | |
| dc.subject.en | Early clinical trial | |
| dc.subject.en | Prediction | |
| dc.subject.en | Prodromal Alzheimer's disease | |
| dc.title.en | Cognitive decline as an outcome and marker of progression toward dementia, in early preventive trials | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/alz.12431 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34482607 | en_US |
| bordeaux.journal | Alzheimer's and Dementia | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03419438 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-11-08T13:44:29Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2021-09-05&rft.eissn=1552-5279%20(Electronic)%201552-5260%20(Linking)&rft.issn=1552-5279%20(Electronic)%201552-5260%20(Linking)&rft.au=MURA,%20Thibault&COLEY,%20Nicola&AMIEVA,%20Helene&BERR,%20Claudine&GABELLE,%20Audrey&rft.genre=article |
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