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dc.rights.licenseopenen_US
dc.contributor.authorCARLES, Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTADDE, Bachirou O.
dc.contributor.authorBERR, Claudine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJACQMIN-GADDA, Helene
dc.contributor.authorCARRIERE, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X
IDREF: 114375747
dc.date.accessioned2021-11-08T10:37:11Z
dc.date.available2021-11-08T10:37:11Z
dc.date.issued2021-09-03
dc.identifier.issn1758-9193 (Electronic)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123772
dc.description.abstractEnBACKGROUND: Thoroughly understanding the temporal associations between cognitive and functional dimensions along the dementia process is fundamental to define preventive measures likely to delay the disease's onset. This work aimed to finely describe the trajectories of cognitive and functional declines, and assess their dynamic bidirectional relationships among subjects at different stages of the dementia process. METHODS: We leveraged extensive repeated data of cognition and functional dependency from the French prospective COGICARE study, designed to better characterize the natural history of cognitive and functional declines around dementia diagnosis. Cognition was measured by the Mini-Mental State Examination, the Isaacs Set Test for verbal fluency, the Benton Visual Retention Test for visuo-spatial memory, and Trail Making Test Part B for executive functioning. Functional dependency was measured by basic and instrumental activities of daily living. The study included 102 cognitively normal, 123 mildly cognitively impaired, and 72 dementia cases with a median of 5 repeated visits over up to 57 months. We used a dynamic causal model which addresses the two essential issues in temporal associations assessment: focusing on intra-individual change and accounting for time. RESULTS: Better cognitive abilities were associated with lower subsequent decline of the functional level among the three clinical stages with an intensification over time but no reciprocity of the association whatever the clinical status. CONCLUSION: This work confirms that the progressive functional dependency could be induced by cognitive impairment. Subjects identified as early as possible with clinically significant cognitive impairments could benefit from preventive measures before the deterioration of activities of daily living and the appearance of dementia clinical signs.
dc.description.sponsorshipModèles statistiques pour la maladie d'Alzheimer et le vieillissement - ANR-15-CE37-0002en_US
dc.description.sponsorshipHistoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé - ANR-07-LVIE-0003en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enActivities of daily living
dc.subject.enCognitive aging
dc.subject.enMini-Mental State Examination
dc.subject.enTemporal association
dc.subject.enCausality
dc.subject.enDementia
dc.title.enDynamic reciprocal relationships between cognitive and functional declines along the Alzheimer's disease continuum in the prospective COGICARE study
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13195-021-00887-4en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34479648en_US
bordeaux.journalAlzheimer's Research and Therapyen_US
bordeaux.page148en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20Research%20and%20Therapy&rft.date=2021-09-03&rft.volume=13&rft.issue=1&rft.spage=148&rft.epage=148&rft.eissn=1758-9193%20(Electronic)&rft.issn=1758-9193%20(Electronic)&rft.au=CARLES,%20Sophie&TADDE,%20Bachirou%20O.&BERR,%20Claudine&HELMER,%20Catherine&JACQMIN-GADDA,%20Helene&rft.genre=article


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