Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
dc.rights.license | open | en_US |
dc.contributor.author | EVANGELOU, E. | |
dc.contributor.author | WARREN, H. R. | |
dc.contributor.author | MOSEN-ANSORENA, D. | |
dc.contributor.author | MIFSUD, B. | |
dc.contributor.author | PAZOKI, R. | |
dc.contributor.author | GAO, H. | |
dc.contributor.author | NTRITSOS, G. | |
dc.contributor.author | DIMOU, N. | |
dc.contributor.author | CABRERA, C. P. | |
dc.contributor.author | KARAMAN, I. | |
dc.contributor.author | NG, F. L. | |
dc.contributor.author | EVANGELOU, M. | |
dc.contributor.author | WITKOWSKA, K. | |
dc.contributor.author | TZANIS, E. | |
dc.contributor.author | HELLWEGE, J. N. | |
dc.contributor.author | GIRI, A. | |
dc.contributor.author | VELEZ EDWARDS, D. R. | |
dc.contributor.author | SUN, Y. V. | |
dc.contributor.author | CHO, K. | |
dc.contributor.author | GAZIANO, J. M. | |
dc.contributor.author | WILSON, P. W. F. | |
dc.contributor.author | TSAO, P. S. | |
dc.contributor.author | KOVESDY, C. P. | |
dc.contributor.author | ESKO, T. | |
dc.contributor.author | MAGI, R. | |
dc.contributor.author | MILANI, L. | |
dc.contributor.author | ALMGREN, P. | |
dc.contributor.author | BOUTIN, T. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DEBETTE, Stephanie | |
dc.contributor.author | DING, J. | |
dc.contributor.author | GIULIANINI, F. | |
dc.contributor.author | HOLLIDAY, E. G. | |
dc.contributor.author | JACKSON, A. U. | |
dc.contributor.author | LI-GAO, R. | |
dc.contributor.author | LIN, W. Y. | |
dc.contributor.author | LUAN, J. | |
dc.contributor.author | MANGINO, M. | |
dc.contributor.author | OLDMEADOW, C. | |
dc.contributor.author | PRINS, B. P. | |
dc.contributor.author | QIAN, Y. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | SARGURUPREMRAJ, Muralidharan | |
dc.contributor.author | SHAH, N. | |
dc.contributor.author | SURENDRAN, P. | |
dc.contributor.author | THERIAULT, S. | |
dc.contributor.author | VERWEIJ, N. | |
dc.contributor.author | WILLEMS, S. M. | |
dc.contributor.author | ZHAO, J. H. | |
dc.contributor.author | AMOUYEL, Philippe | |
dc.contributor.author | CONNELL, J. | |
dc.contributor.author | DE MUTSERT, R. | |
dc.contributor.author | DONEY, A. S. F. | |
dc.contributor.author | FARRALL, M. | |
dc.contributor.author | MENNI, C. | |
dc.contributor.author | MORRIS, A. D. | |
dc.contributor.author | NOORDAM, R. | |
dc.contributor.author | PARE, G. | |
dc.contributor.author | POULTER, N. R. | |
dc.contributor.author | SHIELDS, D. C. | |
dc.contributor.author | STANTON, A. | |
dc.contributor.author | THOM, S. | |
dc.contributor.author | ABECASIS, G. | |
dc.contributor.author | AMIN, N. | |
dc.contributor.author | ARKING, D. E. | |
dc.contributor.author | AYERS, K. L. | |
dc.contributor.author | BARBIERI, C. M. | |
dc.contributor.author | BATINI, C. | |
dc.contributor.author | BIS, J. C. | |
dc.contributor.author | BLAKE, T. | |
dc.contributor.author | BOCHUD, M. | |
dc.contributor.author | BOEHNKE, M. | |
dc.contributor.author | BOERWINKLE, E. | |
dc.contributor.author | BOOMSMA, D. I. | |
dc.contributor.author | BOTTINGER, E. P. | |
dc.contributor.author | BRAUND, P. S. | |
dc.contributor.author | BRUMAT, M. | |
dc.contributor.author | CAMPBELL, A. | |
dc.contributor.author | CAMPBELL, H. | |
dc.contributor.author | CHAKRAVARTI, A. | |
dc.contributor.author | CHAMBERS, J. C. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | CHAUHAN, Ganesh | |
dc.contributor.author | CIULLO, M. | |
dc.contributor.author | COCCA, M. | |
dc.contributor.author | COLLINS, F. | |
dc.contributor.author | CORDELL, H. J. | |
dc.contributor.author | DAVIES, G. | |
dc.contributor.author | BORST, M. H. | |
dc.contributor.author | GEUS, E. J. | |
dc.contributor.author | DEARY, I. J. | |
dc.contributor.author | DEELEN, J. | |
dc.contributor.author | DEL GRECO, M. F. | |
dc.contributor.author | DEMIRKALE, C. Y. | |
dc.contributor.author | DORR, M. | |
dc.contributor.author | EHRET, G. B. | |
dc.contributor.author | ELOSUA, R. | |
dc.contributor.author | ENROTH, S. | |
dc.contributor.author | ERZURUMLUOGLU, A. M. | |
dc.contributor.author | FERREIRA, T. | |
dc.contributor.author | FRANBERG, M. | |
dc.contributor.author | FRANCO, O. H. | |
dc.contributor.author | GANDIN, I. | |
dc.contributor.author | GASPARINI, P. | |
dc.contributor.author | GIEDRAITIS, V. | |
dc.contributor.author | GIEGER, C. | |
dc.contributor.author | GIROTTO, G. | |
dc.contributor.author | GOEL, A. | |
dc.contributor.author | GOW, A. J. | |
dc.contributor.author | GUDNASON, V. | |
dc.contributor.author | GUO, X. | |
dc.contributor.author | GYLLENSTEN, U. | |
dc.contributor.author | HAMSTEN, A. | |
dc.contributor.author | HARRIS, T. B. | |
dc.contributor.author | HARRIS, S. E. | |
dc.contributor.author | HARTMAN, C. A. | |
dc.contributor.author | HAVULINNA, A. S. | |
dc.contributor.author | HICKS, A. A. | |
dc.contributor.author | HOFER, E. | |
dc.contributor.author | HOFMAN, A. | |
dc.contributor.author | HOTTENGA, J. J. | |
dc.contributor.author | HUFFMAN, J. E. | |
dc.contributor.author | HWANG, S. J. | |
dc.contributor.author | INGELSSON, E. | |
dc.contributor.author | JAMES, A. | |
dc.contributor.author | JANSEN, R. | |
dc.contributor.author | JARVELIN, M. R. | |
dc.contributor.author | JOEHANES, R. | |
dc.contributor.author | JOHANSSON, A. | |
dc.contributor.author | JOHNSON, A. D. | |
dc.contributor.author | JOSHI, P. K. | |
dc.contributor.author | JOUSILAHTI, P. | |
dc.contributor.author | JUKEMA, J. W. | |
dc.contributor.author | JULA, A. | |
dc.contributor.author | KAHONEN, M. | |
dc.contributor.author | KATHIRESAN, S. | |
dc.contributor.author | KEAVNEY, B. D. | |
dc.contributor.author | KHAW, K. T. | |
dc.contributor.author | KNEKT, P. | |
dc.contributor.author | KNIGHT, J. | |
dc.contributor.author | KOLCIC, I. | |
dc.contributor.author | KOONER, J. S. | |
dc.contributor.author | KOSKINEN, S. | |
dc.contributor.author | KRISTIANSSON, K. | |
dc.contributor.author | KUTALIK, Z. | |
dc.contributor.author | LAAN, M. | |
dc.contributor.author | LARSON, M. | |
dc.contributor.author | LAUNER, L. J. | |
dc.contributor.author | LEHNE, B. | |
dc.contributor.author | LEHTIMAKI, T. | |
dc.contributor.author | LIEWALD, D. C. M. | |
dc.contributor.author | LIN, L. | |
dc.contributor.author | LIND, L. | |
dc.contributor.author | LINDGREN, C. M. | |
dc.contributor.author | LIU, Y. | |
dc.contributor.author | LOOS, R. J. F. | |
dc.contributor.author | LOPEZ, L. M. | |
dc.contributor.author | LU, Y. | |
dc.contributor.author | LYYTIKAINEN, L. P. | |
dc.contributor.author | MAHAJAN, A. | |
dc.contributor.author | MAMASOULA, C. | |
dc.contributor.author | MARRUGAT, J. | |
dc.contributor.author | MARTEN, J. | |
dc.contributor.author | MILANESCHI, Y. | |
dc.contributor.author | MORGAN, A. | |
dc.contributor.author | MORRIS, A. P. | |
dc.contributor.author | MORRISON, A. C. | |
dc.contributor.author | MUNSON, P. J. | |
dc.contributor.author | NALLS, M. A. | |
dc.contributor.author | NANDAKUMAR, P. | |
dc.contributor.author | NELSON, C. P. | |
dc.contributor.author | NIIRANEN, T. | |
dc.contributor.author | NOLTE, I. M. | |
dc.contributor.author | NUTILE, T. | |
dc.contributor.author | OLDEHINKEL, A. J. | |
dc.contributor.author | OOSTRA, B. A. | |
dc.contributor.author | O'REILLY, P. F. | |
dc.contributor.author | ORG, E. | |
dc.contributor.author | PADMANABHAN, S. | |
dc.contributor.author | PALMAS, W. | |
dc.contributor.author | PALOTIE, A. | |
dc.contributor.author | PATTIE, A. | |
dc.contributor.author | PENNINX, Bwjh | |
dc.contributor.author | PEROLA, M. | |
dc.contributor.author | PETERS, A. | |
dc.contributor.author | POLASEK, O. | |
dc.contributor.author | PRAMSTALLER, P. P. | |
dc.contributor.author | NGUYEN, Q. T. | |
dc.contributor.author | RAITAKARI, O. T. | |
dc.contributor.author | REN, M. | |
dc.contributor.author | RETTIG, R. | |
dc.contributor.author | RICE, K. | |
dc.contributor.author | RIDKER, P. M. | |
dc.contributor.author | RIED, J. S. | |
dc.contributor.author | RIESE, H. | |
dc.contributor.author | RIPATTI, S. | |
dc.contributor.author | ROBINO, A. | |
dc.contributor.author | ROSE, L. M. | |
dc.contributor.author | ROTTER, J. I. | |
dc.contributor.author | RUDAN, I. | |
dc.contributor.author | RUGGIERO, D. | |
dc.contributor.author | SABA, Y. | |
dc.contributor.author | SALA, C. F. | |
dc.contributor.author | SALOMAA, V. | |
dc.contributor.author | SAMANI, N. J. | |
dc.contributor.author | SARIN, A. P. | |
dc.contributor.author | SCHMIDT, R. | |
dc.contributor.author | SCHMIDT, H. | |
dc.contributor.author | SHRINE, N. | |
dc.contributor.author | SISCOVICK, D. | |
dc.contributor.author | SMITH, A. V. | |
dc.contributor.author | SNIEDER, H. | |
dc.contributor.author | SOBER, S. | |
dc.contributor.author | SORICE, R. | |
dc.contributor.author | STARR, J. M. | |
dc.contributor.author | STOTT, D. J. | |
dc.contributor.author | STRACHAN, D. P. | |
dc.contributor.author | STRAWBRIDGE, R. J. | |
dc.contributor.author | SUNDSTROM, J. | |
dc.contributor.author | SWERTZ, M. A. | |
dc.contributor.author | TAYLOR, K. D. | |
dc.contributor.author | TEUMER, A. | |
dc.contributor.author | TOBIN, M. D. | |
dc.contributor.author | TOMASZEWSKI, M. | |
dc.contributor.author | TONIOLO, D. | |
dc.contributor.author | TRAGLIA, M. | |
dc.contributor.author | TROMPET, S. | |
dc.contributor.author | TUOMILEHTO, J. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | TZOURIO, Christophe | |
dc.contributor.author | UITTERLINDEN, A. G. | |
dc.contributor.author | VAEZ, A. | |
dc.contributor.author | VAN DER MOST, P. J. | |
dc.contributor.author | VAN DUIJN, C. M. | |
dc.contributor.author | VERGNAUD, A. C. | |
dc.contributor.author | VERWOERT, G. C. | |
dc.contributor.author | VITART, V. | |
dc.contributor.author | VOLKER, U. | |
dc.contributor.author | VOLLENWEIDER, P. | |
dc.contributor.author | VUCKOVIC, D. | |
dc.contributor.author | WATKINS, H. | |
dc.contributor.author | WILD, S. H. | |
dc.contributor.author | WILLEMSEN, G. | |
dc.contributor.author | WILSON, J. F. | |
dc.contributor.author | WRIGHT, A. F. | |
dc.contributor.author | YAO, J. | |
dc.contributor.author | ZEMUNIK, T. | |
dc.contributor.author | ZHANG, W. | |
dc.contributor.author | ATTIA, J. R. | |
dc.contributor.author | BUTTERWORTH, A. S. | |
dc.contributor.author | CHASMAN, D. I. | |
dc.contributor.author | CONEN, D. | |
dc.contributor.author | CUCCA, F. | |
dc.contributor.author | DANESH, J. | |
dc.contributor.author | HAYWARD, C. | |
dc.contributor.author | HOWSON, J. M. M. | |
dc.contributor.author | LAAKSO, M. | |
dc.contributor.author | LAKATTA, E. G. | |
dc.contributor.author | LANGENBERG, C. | |
dc.contributor.author | MELANDER, O. | |
dc.contributor.author | MOOK-KANAMORI, D. O. | |
dc.contributor.author | PALMER, C. N. A. | |
dc.contributor.author | RISCH, L. | |
dc.contributor.author | SCOTT, R. A. | |
dc.contributor.author | SCOTT, R. J. | |
dc.contributor.author | SEVER, P. | |
dc.contributor.author | SPECTOR, T. D. | |
dc.contributor.author | VAN DER HARST, P. | |
dc.contributor.author | WAREHAM, N. J. | |
dc.contributor.author | ZEGGINI, E. | |
dc.contributor.author | LEVY, D. | |
dc.contributor.author | MUNROE, P. B. | |
dc.contributor.author | NEWTON-CHEH, C. | |
dc.contributor.author | BROWN, M. J. | |
dc.contributor.author | METSPALU, A. | |
dc.contributor.author | HUNG, A. M. | |
dc.contributor.author | O'DONNELL, C. J. | |
dc.contributor.author | EDWARDS, T. L. | |
dc.contributor.author | PSATY, B. M. | |
dc.contributor.author | TZOULAKI, I. | |
dc.contributor.author | BARNES, M. R. | |
dc.contributor.author | WAIN, L. V. | |
dc.contributor.author | ELLIOTT, P. | |
dc.contributor.author | CAULFIELD, M. J. | |
dc.date.accessioned | 2020-11-09T14:57:54Z | |
dc.date.available | 2020-11-09T14:57:54Z | |
dc.date.issued | 2018-10 | |
dc.identifier.issn | 1546-1718 (Electronic) 1061-4036 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/12167 | |
dc.description.abstractEn | High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. | |
dc.language.iso | EN | en_US |
dc.subject.en | HEALTHY | |
dc.subject.en | VINTAGE | |
dc.title.en | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | |
dc.title.alternative | Nat Genet | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s41588-018-0205-x | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 30224653 | en_US |
bordeaux.journal | Nature Genetics | en_US |
bordeaux.page | 1412-1425 | en_US |
bordeaux.volume | 50 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 10 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.team | HEALTHY_BPH | en_US |
bordeaux.team | VINTAGE | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03193866 | |
hal.version | 1 | |
hal.date.transferred | 2021-04-09T08:20:39Z | |
hal.export | true | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Genetics&rft.date=2018-10&rft.volume=50&rft.issue=10&rft.spage=1412-1425&rft.epage=1412-1425&rft.eissn=1546-1718%20(Electronic)%201061-4036%20(Linking)&rft.issn=1546-1718%20(Electronic)%201061-4036%20(Linking)&rft.au=EVANGELOU,%20E.&WARREN,%20H.%20R.&MOSEN-ANSORENA,%20D.&MIFSUD,%20B.&PAZOKI,%20R.&rft.genre=article |
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