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dc.rights.licenseopenen_US
dc.contributor.authorDUFFAU, Pierre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorOZANNE, Alexandra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorLAZARO, Estibaliz
dc.contributor.authorCAZANAVE, Charles
dc.contributor.authorBLANCO, Patrick
dc.contributor.authorRIVIERE, Etienne
dc.contributor.authorDESCLAUX, Arnaud
dc.contributor.authorHYERNARD, Caroline
dc.contributor.authorGENSOUS, Noemie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPELLEGRIN, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.date.accessioned2020-11-03T15:40:00Z
dc.date.available2020-11-03T15:40:00Z
dc.date.issued2018-07-31
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11612
dc.description.abstractEnBACKGROUND: The widespread introduction of combination antiretroviral therapy (cART) has increased survival of HIV+ patients. However, the prevalence of age-related comorbidities remains higher than that of the general population, suggesting that individuals with HIV suffer from accelerated aging. Immune activation, -senescence and inflammation could play an important role in this process. METHODS: The CIADIS (Chronic Immune Activation anD Senescence) sub-study analyzed biomarkers of activation, differentiation, and senescence of T-cells in a cellular-CIADIS weighted score, while biomarkers of inflammation were analyzed in a soluble-CIADIS weighted score using principal component analysis. Adjusted logistic regression and Cox proportional hazard models were used to determine the association between CIADIS weighted scores and 1) the presence of multimorbidity, 2) time to occurrence of the first new age-related comorbidity, and 3) time to death, over a 3-year follow-up period. RESULTS: Of 828 patients with an undetectable viral load, a higher cellular-CIADIS weighted score and higher TNFRI levels were independently associated with the presence of multimorbidity (OR=1.3; 95% CI 1.0-1.6; P=0.02), but the soluble-CIADIS weighted score was not (OR=1.1; 95% CI 0.9-1.3; P=0.33). A higher cellular-CIADIS weighted score (HR=2.2; P < 0.01), higher levels of CD8 activation and a lower CD4/CD8 ratio were associated with a higher risk of age-related comorbidities. Only TNFRI was associated with mortality in a 3-year period. CONCLUSIONS: The cellular-CIADIS weighted score was independently associated with both multimorbidity at inclusion and the risk of new age-related comorbidity during a 3- year follow-up. TNFRI was associated a higher risk for mortality.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.title.enMultimorbidity, age-related comorbidities and mortality: association of activation, senescence and inflammation markers in HIV adults
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000001875en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29762168en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.page1651-1660en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03164773
hal.version1
hal.date.transferred2021-03-10T09:49:21Z
hal.exporttrue
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