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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDHERSIN, Alice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorATGE, Benoit
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMARTINEZ, Béatrice
dc.contributor.authorTITIER, K.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUSSET, Marine
dc.contributor.authorSIDATT CHEIKH EL MOUSTAPH, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVERDUN-ESQUER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOLIMARD, Mathieu
dc.contributor.authorVILLA, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCANAL-RAFFIN, Mireille
dc.date.accessioned2020-11-03T14:31:53Z
dc.date.available2020-11-03T14:31:53Z
dc.date.issued2018-08-20
dc.identifier.issn0003-2654en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11607
dc.description.abstractEn5-Fluorouracil (5-FU) is one of the most widely used antineoplastic drugs handled by healthcare professionals (HCP). To monitor occupational exposure to 5-FU, a highly sensitive ESI-UHPLC-MS/MS method was developed for the assay of its main human metabolite, alpha-fluoro-beta-alanine (FBAL), in urine. After a derivatization step, solid phase extraction was used for the urine. Good linearity (r > 0.996), precision (CV < 14.76%), and accuracy (bias < 12.16%) were achieved. The lower limit of quantification (LOQ), 20 pg ml-1, is the lowest one published to date. Seven urine samples from 73 HCP exposed to 5FU were positive for FBAL, indicating 5FU contamination (9.6%). FBAL urine concentrations ranged from 25 to 301 pg ml-1. Such an efficient analytical tool combining high specificity with high sensitivity is essential for the reliable detection and routine biological monitoring of healthcare professionals occupationally exposed to this widely used antineoplastic drug. This method allows biomonitoring of occupational exposure to 5-fluorouracil in a routine manner, with the aim of assessing the effectiveness of collective and individual protective measures.
dc.language.isoENen_US
dc.subject.enPharmacoEpi-Drugs
dc.subject.enEPICENE
dc.title.enBiomonitoring of occupational exposure to 5-FU by assaying alpha-fluoro-beta-alanine in urine with a highly sensitive UHPLC-MS/MS method
dc.title.alternativeAnalysten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/c8an00479jen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30058665en_US
bordeaux.journalThe Analysten_US
bordeaux.page4110-4117en_US
bordeaux.volume143en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue17en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02987110
hal.version1
hal.date.transferred2020-11-03T14:31:59Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=The%20Analyst&amp;rft.date=2018-08-20&amp;rft.volume=143&amp;rft.issue=17&amp;rft.spage=4110-4117&amp;rft.epage=4110-4117&amp;rft.eissn=0003-2654&amp;rft.issn=0003-2654&amp;rft.au=DHERSIN,%20Alice&amp;ATGE,%20Benoit&amp;MARTINEZ,%20B%C3%A9atrice&amp;TITIER,%20K.&amp;ROUSSET,%20Marine&amp;rft.genre=article


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