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Determinants and outcome of multiple and early recurrent cervical artery dissections

dc.rights.licenseopenen_US
dc.contributor.authorCOMPTER, A.
dc.contributor.authorSCHILLING, S.
dc.contributor.authorVAINEAU, C. J.
dc.contributor.authorGOEGGEL-SIMONETTI, B.
dc.contributor.authorMETSO, T. M.
dc.contributor.authorSOUTHERLAND, A.
dc.contributor.authorPEZZINI, A.
dc.contributor.authorKLOSS, M.
dc.contributor.authorTOUZE, E.
dc.contributor.authorWORRALL, B. B.
dc.contributor.authorTHIJS, V.
dc.contributor.authorBEJOT, Y.
dc.contributor.authorREINER, P.
dc.contributor.authorGROND-GINSBACH, C.
dc.contributor.authorBERSANO, A.
dc.contributor.authorBRANDT, T.
dc.contributor.authorCASO, V.
dc.contributor.authorLYRER, P. A.
dc.contributor.authorTRAENKA, C.
dc.contributor.authorLICHY, C.
dc.contributor.authorMARTIN, J. J.
dc.contributor.authorLEYS, D.
dc.contributor.authorSARIKAYA, H.
dc.contributor.authorBAUMGARTNER, R. W.
dc.contributor.authorJUNG, S.
dc.contributor.authorFISCHER, U.
dc.contributor.authorENGELTER, S. T.
dc.contributor.authorDALLONGEVILLE, J.
dc.contributor.authorCHABRIAT, H.
dc.contributor.authorTATLISUMAK, T.
dc.contributor.authorBOUSSER, M. G.
dc.contributor.authorARNOLD, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.date.accessioned2020-11-02T10:03:42Z
dc.date.available2020-11-02T10:03:42Z
dc.date.issued2018-08-21
dc.identifier.issn0028-3878en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11566
dc.description.abstractEnOBJECTIVE: To assess putative risk factors and outcome of multiple and early recurrent cervical artery dissection (CeAD). METHODS: We combined data from 2 multicenter cohorts and compared patients with multiple CeAD at initial diagnosis, early recurrent CeAD within 3 to 6 months, and single nonrecurrent CeAD. Putative risk factors, clinical characteristics, functional outcome, and risk of recurrent ischemic events were assessed. RESULTS: Of 1,958 patients with CeAD (mean +/- SD age 44.3 +/- 10 years, 43.9% women), 1,588 (81.1%) had single nonrecurrent CeAD, 340 (17.4%) had multiple CeAD, and 30 (1.5%) presented with single CeAD at admission and had early recurrent CeAD. Patients with multiple or early recurrent CeAD did not significantly differ with respect to putative risk factors, clinical presentation, and outcome. In multivariable analyses, patients with multiple or early recurrent CeAD more often had recent infection (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.29-2.53), vertebral artery dissection (OR 1.82, 95% CI 1.34-2.46), family history of stroke (OR 1.55, 95% CI 1.06-2.25), cervical pain (OR 1.36, 95% CI 1.01-1.84), and subarachnoid hemorrhage (OR 2.85, 95% CI 1.01-8.04) at initial presentation compared to patients with single nonrecurrent CeAD. Patients with multiple or early recurrent CeAD also had a higher incidence of cerebral ischemia (hazard ratio 2.77, 95% CI 1.49-5.14) at 3 to 6 months but no difference in functional outcome compared to patients with single nonrecurrent CeAD. CONCLUSION: Patients with multiple and early recurrent CeAD share similar risk factors, clinical characteristics, and functional outcome. Compared to patients with single nonrecurrent CeAD, they are more likely to have recurrent cerebral ischemia at 3 to 6 months, possibly reflecting an underlying transient vasculopathy.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enDeterminants and outcome of multiple and early recurrent cervical artery dissections
dc.title.alternativeNeurologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000006037
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30068628en_US
bordeaux.journalNeurologyen_US
bordeaux.pagee769-e780en_US
bordeaux.volume91en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03162365
hal.version1
hal.date.transferred2021-03-08T13:31:33Z
hal.exporttrue
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