ANTTILA, V.; BULIK-SULLIVAN, B.; FINUCANE, H. K.; WALTERS, R. K.; BRAS, J.; DUNCAN, L.; ESCOTT-PRICE, V.; FALCONE, G. J.; GORMLEY, P.; MALIK, R.; PATSOPOULOS, N. A.; RIPKE, S.; WEI, Z.; YU, D.; LEE, P. H.; TURLEY, P.; GRENIER-BOLEY, B.; CHOURAKI, V.; KAMATANI, Y.; BERR, C.; LETENNEUR, Luc; HANNEQUIN, D.; AMOUYEL, Philippe; BOLAND, A.; DELEUZE, J. F.; DURON, E.; VARDARAJAN, B. N.; REITZ, C.; GOATE, A. M.; HUENTELMAN, M. J.; KAMBOH, M. I.; LARSON, E. B.; ROGAEVA, E.; ST GEORGE-HYSLOP, P.; HAKONARSON, H.; KUKULL, W. A.; FARRER, L. A.; BARNES, L. L.; BEACH, T. G.; DEMIRCI, F. Y.; HEAD, E.; HULETTE, C. M.; JICHA, G. A.; KAUWE, J. S. K.; KAYE, J. A.; LEVERENZ, J. B.; LEVEY, A. I.; LIEBERMAN, A. P.; PANKRATZ, V. S.; POON, W. W.; QUINN, J. F.; SAYKIN, A. J.; SCHNEIDER, L. S.; SMITH, A. G.; SONNEN, J. A.; STERN, R. A.; VAN DEERLIN, V. M.; VAN ELDIK, L. J.; HAROLD, D.; RUSSO, G.; RUBINSZTEIN, D. C.; BAYER, A.; TSOLAKI, M.; PROITSI, P.; FOX, N. C.; HAMPEL, H.; OWEN, M. J.; MEAD, S.; PASSMORE, P.; MORGAN, K.; NOTHEN, M. M.; ROSSOR, M.; LUPTON, M. K.; HOFFMANN, P.; KORNHUBER, J.; LAWLOR, B.; MCQUILLIN, A.; AL-CHALABI, A.; BIS, J. C.; RUIZ, A.; BOADA, M.; SESHADRI, Sudha; BEISER, A.; RICE, K.; VAN DER LEE, S. J.; DE JAGER, P. L.; GESCHWIND, D. H.; RIEMENSCHNEIDER, M.; RIEDEL-HELLER, S.; ROTTER, J. I.; RANSMAYR, G.; HYMAN, B. T.; CRUCHAGA, C.; ALEGRET, M.; WINSVOLD, B.; PALTA, P.; FARH, K. H.; CUENCA-LEON, E.; FURLOTTE, N.; KURTH, T.; LIGTHART, L.; TERWINDT, G. M.; FREILINGER, T.; RAN, C.; GORDON, S. D.; BORCK, G.; ADAMS, H. H. H.; LEHTIMAKI, T.; WEDENOJA, J.; BURING, J. E.; SCHURKS, M.; HRAFNSDOTTIR, M.; HOTTENGA, J. J.; PENNINX, B.; ARTTO, V.; KAUNISTO, M.; VEPSALAINEN, S.; MARTIN, N. G.; MONTGOMERY, G. W.; KURKI, M. 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L.; MARSON, A.; BECKER, F.; STROINK, H.; ZIMPRICH, F.; GASSER, T.; GIBBS, R.; HEUTINK, P.; MARTINEZ, M.; MORRIS, H. R.; SHARMA, M.; RYTEN, M.; MOK, K. Y.; PULIT, S.; BEVAN, S.; HOLLIDAY, E.; ATTIA, J.; BATTEY, T.; BONCORAGLIO, G.; THIJS, V.; CHEN, W. M.; MITCHELL, B.; ROTHWELL, P.; SHARMA, P.; SUDLOW, C.; VICENTE, A.; MARKUS, H.; KOURKOULIS, C.; PERA, J.; RAFFELD, M.; SILLIMAN, S.; BORASKA PERICA, V.; THORNTON, L. M.; HUCKINS, L. M.; WILLIAM RAYNER, N.; LEWIS, C. M.; GRATACOS, M.; RYBAKOWSKI, F.; KESKI-RAHKONEN, A.; RAEVUORI, A.; HUDSON, J. I.; REICHBORN-KJENNERUD, T.; MONTELEONE, P.; KARWAUTZ, A.; MANNIK, K.; BAKER, J. H.; O'TOOLE, J. K.; TRACE, S. E.; DAVIS, O. S. P.; HELDER, S. G.; EHRLICH, S.; HERPERTZ-DAHLMANN, B.; DANNER, U. N.; VAN ELBURG, A. A.; CLEMENTI, M.; FORZAN, M.; DOCAMPO, E.; LISSOWSKA, J.; HAUSER, J.; TORTORELLA, A.; MAJ, M.; GONIDAKIS, F.; TZIOUVAS, K.; PAPEZOVA, H.; YILMAZ, Z.; WAGNER, G.; COHEN-WOODS, S.; HERMS, S.; JULIA, A.; RABIONET, R.; DICK, D. M.; RIPATTI, S.; ANDREASSEN, O. A.; ESPESETH, T.; LUNDERVOLD, A. J.; STEEN, V. M.; PINTO, D.; SCHERER, S. W.; ASCHAUER, H.; SCHOSSER, A.; ALFREDSSON, L.; PADYUKOV, L.; HALMI, K. A.; MITCHELL, J.; STROBER, M.; BERGEN, A. W.; KAYE, W.; SZATKIEWICZ, J. P.; CORMAND, B.; RAMOS-QUIROGA, J. A.; SANCHEZ-MORA, C.; RIBASES, M.; CASAS, M.; HERVAS, A.; ARRANZ, M. J.; HAAVIK, J.; ZAYATS, T.; JOHANSSON, S.; WILLIAMS, N.; DEMPFLE, A.; ROTHENBERGER, A.; KUNTSI, J.; OADES, R. D.; BANASCHEWSKI, T.; FRANKE, B.; BUITELAAR, J. K.; ARIAS VASQUEZ, A.; DOYLE, A. E.; REIF, A.; LESCH, K. P.; FREITAG, C.; RIVERO, O.; PALMASON, H.; ROMANOS, M.; LANGLEY, K.; RIETSCHEL, M.; WITT, S. H.; DALSGAARD, S.; BORGLUM, A. D.; WALDMAN, I.; WILMOT, B.; MOLLY, N.; BAU, C. H. D.; CROSBIE, J.; SCHACHAR, R.; LOO, S. K.; MCGOUGH, J. J.; GREVET, E. H.; MEDLAND, S. E.; ROBINSON, E.; WEISS, L. 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C.; STOGMANN, E.; SUBRAMANIAM, M.; TONCHEVA, D.; WADDINGTON, J.; WALTERS, J.; WEISER, M.; CHENG, W.; CLONINGER, R.; CURTIS, D.; GEJMAN, P. V.; HENSKENS, F.; MATTINGSDAL, M.; OH, S. Y.; SCOTT, R.; WEBB, B.; BREEN, G.; CHURCHHOUSE, C.; BULIK, C. M.; DALY, M.; DICHGANS, M.; FARAONE, S. V.; GUERREIRO, R.; HOLMANS, P.; KENDLER, K. S.; KOELEMAN, B.; MATHEWS, C. A.; PRICE, A.; SCHARF, J.; SKLAR, P.; WILLIAMS, J.; WOOD, N. W.; COTSAPAS, C.; PALOTIE, A.; SMOLLER, J. W.; SULLIVAN, P.; ROSAND, J.; CORVIN, A.; NEALE, B. M.; SCHOTT, J. M.; ANNEY, R.; ELIA, J.; GRIGOROIU-SERBANESCU, M.; EDENBERG, H. J.; MURRAY, R.

doi:10.1126/science.aap8757

dc.rights.license	open	en_US
dc.contributor.author	ANTTILA, V.
dc.contributor.author	BULIK-SULLIVAN, B.
dc.contributor.author	FINUCANE, H. K.
dc.contributor.author	WALTERS, R. K.
dc.contributor.author	BRAS, J.
dc.contributor.author	DUNCAN, L.
dc.contributor.author	ESCOTT-PRICE, V.
dc.contributor.author	FALCONE, G. J.
dc.contributor.author	GORMLEY, P.
dc.contributor.author	MALIK, R.
dc.contributor.author	PATSOPOULOS, N. A.
dc.contributor.author	RIPKE, S.
dc.contributor.author	WEI, Z.
dc.contributor.author	YU, D.
dc.contributor.author	LEE, P. H.
dc.contributor.author	TURLEY, P.
dc.contributor.author	GRENIER-BOLEY, B.
dc.contributor.author	CHOURAKI, V.
dc.contributor.author	KAMATANI, Y.
dc.contributor.author	BERR, C.
hal.structure.identifier	Bordeaux population health [BPH]
dc.contributor.author	LETENNEUR, Luc
dc.contributor.author	HANNEQUIN, D.
dc.contributor.author	AMOUYEL, Philippe
dc.contributor.author	BOLAND, A.
dc.contributor.author	DELEUZE, J. F.
dc.contributor.author	DURON, E.
dc.contributor.author	VARDARAJAN, B. N.
dc.contributor.author	REITZ, C.
dc.contributor.author	GOATE, A. M.
dc.contributor.author	HUENTELMAN, M. J.
dc.contributor.author	KAMBOH, M. I.
dc.contributor.author	LARSON, E. B.
dc.contributor.author	ROGAEVA, E.
dc.contributor.author	ST GEORGE-HYSLOP, P.
dc.contributor.author	HAKONARSON, H.
dc.contributor.author	KUKULL, W. A.
dc.contributor.author	FARRER, L. A.
dc.contributor.author	BARNES, L. L.
dc.contributor.author	BEACH, T. G.
dc.contributor.author	DEMIRCI, F. Y.
dc.contributor.author	HEAD, E.
dc.contributor.author	HULETTE, C. M.
dc.contributor.author	JICHA, G. A.
dc.contributor.author	KAUWE, J. S. K.
dc.contributor.author	KAYE, J. A.
dc.contributor.author	LEVERENZ, J. B.
dc.contributor.author	LEVEY, A. I.
dc.contributor.author	LIEBERMAN, A. P.
dc.contributor.author	PANKRATZ, V. S.
dc.contributor.author	POON, W. W.
dc.contributor.author	QUINN, J. F.
dc.contributor.author	SAYKIN, A. J.
dc.contributor.author	SCHNEIDER, L. S.
dc.contributor.author	SMITH, A. G.
dc.contributor.author	SONNEN, J. A.
dc.contributor.author	STERN, R. A.
dc.contributor.author	VAN DEERLIN, V. M.
dc.contributor.author	VAN ELDIK, L. J.
dc.contributor.author	HAROLD, D.
dc.contributor.author	RUSSO, G.
dc.contributor.author	RUBINSZTEIN, D. C.
dc.contributor.author	BAYER, A.
dc.contributor.author	TSOLAKI, M.
dc.contributor.author	PROITSI, P.
dc.contributor.author	FOX, N. C.
dc.contributor.author	HAMPEL, H.
dc.contributor.author	OWEN, M. J.
dc.contributor.author	MEAD, S.
dc.contributor.author	PASSMORE, P.
dc.contributor.author	MORGAN, K.
dc.contributor.author	NOTHEN, M. M.
dc.contributor.author	ROSSOR, M.
dc.contributor.author	LUPTON, M. K.
dc.contributor.author	HOFFMANN, P.
dc.contributor.author	KORNHUBER, J.
dc.contributor.author	LAWLOR, B.
dc.contributor.author	MCQUILLIN, A.
dc.contributor.author	AL-CHALABI, A.
dc.contributor.author	BIS, J. C.
dc.contributor.author	RUIZ, A.
dc.contributor.author	BOADA, M.
dc.contributor.author	SESHADRI, Sudha
dc.contributor.author	BEISER, A.
dc.contributor.author	RICE, K.
dc.contributor.author	VAN DER LEE, S. J.
dc.contributor.author	DE JAGER, P. L.
dc.contributor.author	GESCHWIND, D. H.
dc.contributor.author	RIEMENSCHNEIDER, M.
dc.contributor.author	RIEDEL-HELLER, S.
dc.contributor.author	ROTTER, J. I.
dc.contributor.author	RANSMAYR, G.
dc.contributor.author	HYMAN, B. T.
dc.contributor.author	CRUCHAGA, C.
dc.contributor.author	ALEGRET, M.
dc.contributor.author	WINSVOLD, B.
dc.contributor.author	PALTA, P.
dc.contributor.author	FARH, K. H.
dc.contributor.author	CUENCA-LEON, E.
dc.contributor.author	FURLOTTE, N.
dc.contributor.author	KURTH, T.
dc.contributor.author	LIGTHART, L.
dc.contributor.author	TERWINDT, G. M.
dc.contributor.author	FREILINGER, T.
dc.contributor.author	RAN, C.
dc.contributor.author	GORDON, S. D.
dc.contributor.author	BORCK, G.
dc.contributor.author	ADAMS, H. H. H.
dc.contributor.author	LEHTIMAKI, T.
dc.contributor.author	WEDENOJA, J.
dc.contributor.author	BURING, J. E.
dc.contributor.author	SCHURKS, M.
dc.contributor.author	HRAFNSDOTTIR, M.
dc.contributor.author	HOTTENGA, J. J.
dc.contributor.author	PENNINX, B.
dc.contributor.author	ARTTO, V.
dc.contributor.author	KAUNISTO, M.
dc.contributor.author	VEPSALAINEN, S.
dc.contributor.author	MARTIN, N. G.
dc.contributor.author	MONTGOMERY, G. W.
dc.contributor.author	KURKI, M. I.
dc.contributor.author	HAMALAINEN, E.
dc.contributor.author	HUANG, H.
dc.contributor.author	HUANG, J.
dc.contributor.author	SANDOR, C.
dc.contributor.author	WEBBER, C.
dc.contributor.author	MULLER-MYHSOK, B.
dc.contributor.author	SCHREIBER, S.
dc.contributor.author	SALOMAA, V.
dc.contributor.author	LOEHRER, E.
dc.contributor.author	GOBEL, H.
dc.contributor.author	MACAYA, A.
dc.contributor.author	POZO-ROSICH, P.
dc.contributor.author	HANSEN, T.
dc.contributor.author	WERGE, T.
dc.contributor.author	KAPRIO, J.
dc.contributor.author	METSPALU, A.
dc.contributor.author	KUBISCH, C.
dc.contributor.author	FERRARI, M. D.
dc.contributor.author	BELIN, A. C.
dc.contributor.author	VAN DEN MAAGDENBERG, Amjm
dc.contributor.author	ZWART, J. A.
dc.contributor.author	BOOMSMA, D.
dc.contributor.author	ERIKSSON, N.
dc.contributor.author	OLESEN, J.
dc.contributor.author	CHASMAN, D. I.
dc.contributor.author	NYHOLT, D. R.
dc.contributor.author	AVBERSEK, A.
dc.contributor.author	BAUM, L.
dc.contributor.author	BERKOVIC, S.
dc.contributor.author	BRADFIELD, J.
dc.contributor.author	BUONO, R.
dc.contributor.author	CATARINO, C. B.
dc.contributor.author	COSSETTE, P.
dc.contributor.author	DE JONGHE, P.
dc.contributor.author	DEPONDT, C.
dc.contributor.author	DLUGOS, D.
dc.contributor.author	FERRARO, T. N.
dc.contributor.author	FRENCH, J.
dc.contributor.author	HJALGRIM, H.
dc.contributor.author	JAMNADAS-KHODA, J.
dc.contributor.author	KALVIAINEN, R.
dc.contributor.author	KUNZ, W. S.
dc.contributor.author	LERCHE, H.
dc.contributor.author	LEU, C.
dc.contributor.author	LINDHOUT, D.
dc.contributor.author	LO, W.
dc.contributor.author	LOWENSTEIN, D.
dc.contributor.author	MCCORMACK, M.
dc.contributor.author	MOLLER, R. S.
dc.contributor.author	MOLLOY, A.
dc.contributor.author	NG, P. W.
dc.contributor.author	OLIVER, K.
dc.contributor.author	PRIVITERA, M.
dc.contributor.author	RADTKE, R.
dc.contributor.author	RUPPERT, A. K.
dc.contributor.author	SANDER, T.
dc.contributor.author	SCHACHTER, S.
dc.contributor.author	SCHANKIN, C.
dc.contributor.author	SCHEFFER, I.
dc.contributor.author	SCHOCH, S.
dc.contributor.author	SISODIYA, S. M.
dc.contributor.author	SMITH, P.
dc.contributor.author	SPERLING, M.
dc.contributor.author	STRIANO, P.
dc.contributor.author	SURGES, R.
dc.contributor.author	THOMAS, G. N.
dc.contributor.author	VISSCHER, F.
dc.contributor.author	WHELAN, C. D.
dc.contributor.author	ZARA, F.
dc.contributor.author	HEINZEN, E. L.
dc.contributor.author	MARSON, A.
dc.contributor.author	BECKER, F.
dc.contributor.author	STROINK, H.
dc.contributor.author	ZIMPRICH, F.
dc.contributor.author	GASSER, T.
dc.contributor.author	GIBBS, R.
dc.contributor.author	HEUTINK, P.
dc.contributor.author	MARTINEZ, M.
dc.contributor.author	MORRIS, H. R.
dc.contributor.author	SHARMA, M.
dc.contributor.author	RYTEN, M.
dc.contributor.author	MOK, K. Y.
dc.contributor.author	PULIT, S.
dc.contributor.author	BEVAN, S.
dc.contributor.author	HOLLIDAY, E.
dc.contributor.author	ATTIA, J.
dc.contributor.author	BATTEY, T.
dc.contributor.author	BONCORAGLIO, G.
dc.contributor.author	THIJS, V.
dc.contributor.author	CHEN, W. M.
dc.contributor.author	MITCHELL, B.
dc.contributor.author	ROTHWELL, P.
dc.contributor.author	SHARMA, P.
dc.contributor.author	SUDLOW, C.
dc.contributor.author	VICENTE, A.
dc.contributor.author	MARKUS, H.
dc.contributor.author	KOURKOULIS, C.
dc.contributor.author	PERA, J.
dc.contributor.author	RAFFELD, M.
dc.contributor.author	SILLIMAN, S.
dc.contributor.author	BORASKA PERICA, V.
dc.contributor.author	THORNTON, L. M.
dc.contributor.author	HUCKINS, L. M.
dc.contributor.author	WILLIAM RAYNER, N.
dc.contributor.author	LEWIS, C. M.
dc.contributor.author	GRATACOS, M.
dc.contributor.author	RYBAKOWSKI, F.
dc.contributor.author	KESKI-RAHKONEN, A.
dc.contributor.author	RAEVUORI, A.
dc.contributor.author	HUDSON, J. I.
dc.contributor.author	REICHBORN-KJENNERUD, T.
dc.contributor.author	MONTELEONE, P.
dc.contributor.author	KARWAUTZ, A.
dc.contributor.author	MANNIK, K.
dc.contributor.author	BAKER, J. H.
dc.contributor.author	O'TOOLE, J. K.
dc.contributor.author	TRACE, S. E.
dc.contributor.author	DAVIS, O. S. P.
dc.contributor.author	HELDER, S. G.
dc.contributor.author	EHRLICH, S.
dc.contributor.author	HERPERTZ-DAHLMANN, B.
dc.contributor.author	DANNER, U. N.
dc.contributor.author	VAN ELBURG, A. A.
dc.contributor.author	CLEMENTI, M.
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dc.contributor.author	OH, S. Y.
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dc.contributor.author	WEBB, B.
dc.contributor.author	BREEN, G.
dc.contributor.author	CHURCHHOUSE, C.
dc.contributor.author	BULIK, C. M.
dc.contributor.author	DALY, M.
dc.contributor.author	DICHGANS, M.
dc.contributor.author	FARAONE, S. V.
dc.contributor.author	GUERREIRO, R.
dc.contributor.author	HOLMANS, P.
dc.contributor.author	KENDLER, K. S.
dc.contributor.author	KOELEMAN, B.
dc.contributor.author	MATHEWS, C. A.
dc.contributor.author	PRICE, A.
dc.contributor.author	SCHARF, J.
dc.contributor.author	SKLAR, P.
dc.contributor.author	WILLIAMS, J.
dc.contributor.author	WOOD, N. W.
dc.contributor.author	COTSAPAS, C.
dc.contributor.author	PALOTIE, A.
dc.contributor.author	SMOLLER, J. W.
dc.contributor.author	SULLIVAN, P.
dc.contributor.author	ROSAND, J.
dc.contributor.author	CORVIN, A.
dc.contributor.author	NEALE, B. M.
dc.contributor.author	SCHOTT, J. M.
dc.contributor.author	ANNEY, R.
dc.contributor.author	ELIA, J.
dc.contributor.author	GRIGOROIU-SERBANESCU, M.
dc.contributor.author	EDENBERG, H. J.
dc.contributor.author	MURRAY, R.
dc.date.accessioned	2020-10-26T15:33:42Z
dc.date.available	2020-10-26T15:33:42Z
dc.date.issued	2018-06-22
dc.identifier.issn	1095-9203 (Electronic) 0036-8075 (Linking)	en_US
dc.identifier.uri	https://oskar-bordeaux.fr/handle/20.500.12278/11482
dc.description.abstractEn	Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
dc.language.iso	EN	en_US
dc.subject.en	SEPIA
dc.title.en	Analysis of shared heritability in common disorders of the brain
dc.title.alternative	Science	en_US
dc.type	Article de revue	en_US
dc.identifier.doi	10.1126/science.aap8757	en_US
dc.subject.hal	Sciences du Vivant [q-bio]/Santé publique et épidémiologie	en_US
dc.identifier.pubmed	29930110	en_US
bordeaux.journal	Science (New York, N.Y.)	en_US
bordeaux.volume	360	en_US
bordeaux.hal.laboratories	Bordeaux Population Health Research Center (BPH) - UMR 1219	en_US
bordeaux.issue	6395	en_US
bordeaux.institution	Université de Bordeaux	en_US
bordeaux.peerReviewed	oui	en_US
bordeaux.inpress	non	en_US
hal.export	false
bordeaux.COinS	ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20(New%20York,%20N.Y.)&rft.date=2018-06-22&rft.volume=360&rft.issue=6395&rft.eissn=1095-9203%20(Electronic)%200036-8075%20(Linking)&rft.issn=1095-9203%20(Electronic)%200036-8075%20(Linking)&rft.au=ANTTILA,%20V.&BULIK-SULLIVAN,%20B.&FINUCANE,%20H.%20K.&WALTERS,%20R.%20K.&BRAS,%20J.&rft.genre=article

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Analysis of shared heritability in common disorders of the brain

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