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Value of chest X-ray in TB diagnosis in HIV-infected children living in resource-limited countries: the ANRS 12229-PAANTHER 01 study

dc.rights.licenseopenen_US
dc.contributor.authorBERTELOOT, L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMARCY, Olivier
dc.contributor.authorNGUYEN, B.
dc.contributor.authorUNG, V.
dc.contributor.authorTEJIOKEM, M.
dc.contributor.authorNACRO, B.
dc.contributor.authorGOYET, S.
dc.contributor.authorDIM, B.
dc.contributor.authorBLANCHE, S.
dc.contributor.authorBORAND, L.
dc.contributor.authorMSELLATI, P.
dc.contributor.authorDELACOURT, C.
dc.date.accessioned2020-10-20T08:13:00Z
dc.date.available2020-10-20T08:13:00Z
dc.date.issued2018-08-01
dc.identifier.issn1815-7920 (Electronic) 1027-3719 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11452
dc.description.abstractEnOBJECTIVE: To evaluate inter-reader agreement and diagnostic accuracy of chest radiography (CXR) in the diagnosis of tuberculosis (TB) in children with human immunodeficiency virus (HIV) infection. DESIGN: HIV-infected children with clinically suspected TB were enrolled in a prospective study conducted in Burkina Faso, Cambodia, Cameroon and Viet Nam from April 2010 to December 2014. Three readers-a local radiologist, a paediatric pulmonologist and a paediatric radiologist-independently reviewed the CXRs. Inter-reader agreement was then assessed using the kappa coefficient. Diagnostic accuracy of CXR was assessed in culture-confirmed cases and controls. RESULTS: A total of 403 children (median age 7.3 years, interquartile range 3.5-9.7; 49.6% males) were enrolled. Inter-reader agreement was as follows: between local radiologist and paediatric pulmonologist, kappa = 0.36 (95%CI 0.27-0.45); local radiologist and paediatric radiologist, kappa = 0.16 (95%CI 0.08-0.24); and paediatric pulmonologist and paediatric radiologist, kappa = 0.30 (95%CI 0.21-0.40). Among 51 cases and 151 controls, after a consensus, CXR had a sensitivity of 71.4% (95%CI 58.8-84.1) and a specificity of 50.0% (95%CI 41.9-58.1). Alveolar opacities and enlarged lymph nodes on CXR had limited specificity for TB (64.7% and 70.2%, respectively). Miliary and/or nodular opacities patterns on CXR were more specific to TB (specificity 94.3%). CONCLUSION: CXR showed poor-to-fair inter-reader agreement and limited diagnostic accuracy for TB in HIV-infected children, likely due to comorbidities. Radiological criteria for this specific population require further investigation.
dc.language.isoENen_US
dc.subject.enIDLIC
dc.title.enValue of chest X-ray in TB diagnosis in HIV-infected children living in resource-limited countries: the ANRS 12229-PAANTHER 01 study
dc.title.alternativeInt J Tuberc Lung Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.5588/ijtld.18.0122en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29991391en_US
bordeaux.journalInternational Journal of Tuberculosis and Lung Diseaseen_US
bordeaux.page844-850en_US
bordeaux.volume22en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03163382
hal.version1
hal.date.transferred2021-03-09T10:22:22Z
hal.exporttrue
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