Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BENARD-LARIBIERE, Anne | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PAMBRUN, Elodie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SUTTER-DALLAY, Anne-Laure | |
| dc.contributor.author | GAUTIER, S. | |
| dc.contributor.author | HURAULT-DELARUE, C. | |
| dc.contributor.author | DAMASE-MICHEL, C. | |
| dc.contributor.author | LACROIX, I. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BEGAUD, Bernard | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PARIENTE, Antoine
IDREF: 13395711X | |
| dc.date.accessioned | 2020-10-20T06:39:16Z | |
| dc.date.available | 2020-10-20T06:39:16Z | |
| dc.date.issued | 2018-08 | |
| dc.identifier.issn | 1365-2125 (Electronic) 0306-5251 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/11444 | |
| dc.description.abstractEn | AIMS: We explored the patterns of antidepressant use during pregnancy. METHODS: A cohort of women who started a pregnancy in 2014 was identified using data from the French reimbursement healthcare system (covering approximately 99% of the population). Antidepressant usage (initiated before or during pregnancy) was assessed. Explored changes in antidepressant treatment were: associations, switches, discontinuation and resumption of antidepressants during pregnancy. RESULTS: The cohort included 766 508 pregnancies (755 519 women). Antidepressant use during pregnancy was 25.7 per 1000 [95% CI: 25.3-26.0]. New use concerned 3.9 per 1000 [95% CI: 3.7-4.0]; the most initiated class during pregnancy was selective serotonin reuptake inhibitors (SSRIs), while the most prescribed individual drug in second and third trimesters was amitriptyline, a tricyclic. Most changes were observed before pregnancy and during the first trimester: 63% of ongoing treatments in the year before pregnancy were discontinued before conception; 68% of treatments maintained after conception were discontinued during the first trimester; switches or antidepressant associations mostly occurred during the periconceptional period or during the first trimester. Regardless of initial antidepressant, switches to sertraline were the most frequent. Associations mainly consisted of a prescription of tri-/tetracyclic or mirtazapine/mianserin in addition to an SSRI. Discontinuation during pregnancy led to treatment resumption in 22% of pregnancies. CONCLUSIONS: These results suggest that pregnancy was planned or the treatment especially adapted in accordance with existing recommendations in a large proportion of women under antidepressants or in whom such treatments have been initiated after starting a pregnancy. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | PharmacoEpi-Drugs | |
| dc.title.en | Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study | |
| dc.title.alternative | Br J Clin Pharmacol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/bcp.13608 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29665098 | en_US |
| bordeaux.journal | British Journal of Clinical Pharmacology | en_US |
| bordeaux.page | 1764-1775 | en_US |
| bordeaux.volume | 84 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03163232 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-09T09:39:50Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British%20Journal%20of%20Clinical%20Pharmacology&rft.date=2018-08&rft.volume=84&rft.issue=8&rft.spage=1764-1775&rft.epage=1764-1775&rft.eissn=1365-2125%20(Electronic)%200306-5251%20(Linking)&rft.issn=1365-2125%20(Electronic)%200306-5251%20(Linking)&rft.au=BENARD-LARIBIERE,%20Anne&PAMBRUN,%20Elodie&SUTTER-DALLAY,%20Anne-Laure&GAUTIER,%20S.&HURAULT-DELARUE,%20C.&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||