Body Mass Index and The Risk of Serious Non-Aids Events and All Cause Mortality in Treated Hiv-Positive Individuals: D: A: D Cohort Analysis
| dc.rights.license | open | en_US |
| dc.contributor.author | ACHHRA, A. C. | |
| dc.contributor.author | SABIN, C. | |
| dc.contributor.author | RYOM, L. | |
| dc.contributor.author | HATLEBERG, C. | |
| dc.contributor.author | ANTONELLA D'AMINIO, M. | |
| dc.contributor.author | WIT, S. | |
| dc.contributor.author | PHILLIPS, A. | |
| dc.contributor.author | PRADIER, C. | |
| dc.contributor.author | WEBER, R. | |
| dc.contributor.author | REISS, P. | |
| dc.contributor.author | EL-SADR, W. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BONNET, Fabrice | |
| dc.contributor.author | MOCROFT, A. | |
| dc.contributor.author | LUNDGREN, J. | |
| dc.contributor.author | LAW, M. G. | |
| dc.date.accessioned | 2020-10-19T07:44:38Z | |
| dc.date.available | 2020-10-19T07:44:38Z | |
| dc.date.issued | 2018-08-15 | |
| dc.identifier.issn | 1944-7884 (Electronic) 1525-4135 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/11396 | |
| dc.description.abstractEn | BACKGROUND: The relationship between body mass index (BMI) [weight (kg)/height (m)] and serious non-AIDS events is not well understood. METHODS: We followed D:A:D study participants on antiretroviral therapy from their first BMI measurement to the first occurrence of the endpoint or end of follow-up (N = 41,149 followed for 295,147 person-years). The endpoints were cardiovascular disease (CVD); diabetes; non-AIDS-defining cancers (NADCs) and BMI-NADCs (cancers known to be associated with BMI in general population); and all-cause mortality. Using Poisson regression models, we analyzed BMI as time-updated, lagged by 1 year, and categorized at: 18.5, 23, 25, 27.5, and 30 kg/m. RESULTS: Participants were largely male (73%) with the mean age of 40 years (SD 9.7) and baseline median BMI of 23.3 (interquartile range: 21.2-25.7). Overall, BMI showed a statistically significant J-shaped relationship with the risk of all outcomes except diabetes. The relative risk (RR) for the BMI of <18.5 and >30 (95% confidence interval) compared with 23-25, respectively, was as follows: CVD: 1.46 (1.15-1.84) and 1.31 (1.03-1.67); NADCs: 1.78 (1.39-2.28) and 1.17 (0.88-1.54); and "BMI-NADCs": 1.29 (0.66-2.55) and 1.92 (1.10-3.36). For all-cause mortality, there was an interaction by sex (P < 0.001): RR in males: 2.47 (2.12-2.89) and 1.21 (0.97-1.50); and in females: 1.60 (1.30-1.98) and 1.02 (0.74-1.42). RR remained around 1 for intermediate categories of BMI. The risk of diabetes linearly increased with increasing BMI (P < 0.001). CONCLUSIONS: Risk of CVD, a range of cancers, and all-cause mortality increased at low BMI (<18.5) and then tended to increase only at BMI > 30 with a relatively low risk at BMI of 23-25 and 25-30. High BMI was also associated with risk of diabetes. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | MORPH3Eus | |
| dc.title.en | Body Mass Index and The Risk of Serious Non-Aids Events and All Cause Mortality in Treated Hiv-Positive Individuals: D: A: D Cohort Analysis | |
| dc.title.alternative | J Acquir Immune Defic Syndr | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/qai.0000000000001722 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29771788 | en_US |
| bordeaux.journal | Journal of Acquired Immune Deficiency Syndromes | en_US |
| bordeaux.page | 579-588 | en_US |
| bordeaux.volume | 78 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03163258 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-09T09:44:00Z | |
| hal.export | true | |
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