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Prognostic impact of early recovering acute kidney injury following liver transplantation: a multicenter retrospective study.

dc.rights.licenseauthentificationen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorDEWITTE, Antoine
dc.contributor.authorDEFAYE, Mylène
dc.contributor.authorDAHMI, Anissa
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorOUATTARA, Alexandre
dc.contributor.authorJOANNES-BOYAU, Olivier
dc.contributor.authorCHERMAK, Faiza
dc.contributor.authorCHICHE, Laurence
dc.contributor.authorLAURENT, Christophe
dc.contributor.authorBATTELIER, Mathieu
dc.contributor.authorSIGAUT, Stéphanie
dc.contributor.authorKHOY-EAR, Linda
dc.contributor.authorGRIGORESCO, Bénédicte
dc.contributor.authorCAUCHY, François
dc.contributor.authorFRANCOZ, Claire
dc.contributor.authorPAUGAM BURTZ, Catherine
dc.contributor.authorJANNY, Sylvie
dc.contributor.authorWEISS, Emmanuel
dc.date.accessioned2021-10-21T08:49:57Z
dc.date.available2021-10-21T08:49:57Z
dc.date.issued2021-06-23
dc.identifier.issn1534-6080en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112858
dc.description.abstractEnAcute Kidney Injury (AKI) is a common complication after liver transplantation (LT) but the specific impact of rapidly resolving AKI is not elucidated. This study investigates the factors associated with early recovery from AKI and its association with post-LT outcomes. Retrospective analysis of 441 liver transplant recipients with end-stage liver disease without pretransplant renal impairment. AKI was defined according to KDIGO criteria and early renal recovery by its disappearance within 7 days post-LT. 146 patients (32%) developed a post-LT AKI, of whom 99 (69%) recovered early and 45 (31%) did not. Factors associated with early recovery were KDIGO stage 1 (OR:14.11; 95%CI:5.59-40.22; P50 % (OR:4.50; 95%CI:1.67-13.46; P=0.003) and AST peak value <1000 U/L (OR:4.07; 95%CI:1.64-10.75; P=0.002) within 48h post-LT. Patients with early recovery had a renal prognosis similar to that of patients without AKI with no difference in estimated glomerular filtration rate between D7 and one year. Their relative risk of developing CKD was 0.88 (95% CI: 0.55-1.41; P=0.6) with survival identical to patients without AKI and better than patients without early recovery (P<0.0001). Most patients with post-LT AKI recover early and have a similar renal prognosis and survival to those without post-LT AKI. Factors associated with early renal recovery are related to the stage of AKI, the extent of liver injury and the early graft function. Patients at risk of not recovering may benefit the most from perioperative protective strategies, particularly those aimed at minimising the adverse effects of CNI.
dc.language.isoENen_US
dc.subjectRecherches cliniques
dc.title.enPrognostic impact of early recovering acute kidney injury following liver transplantation: a multicenter retrospective study.
dc.title.alternativeTransplantationen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/TP.0000000000003865en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaireen_US
dc.identifier.pubmed34172644en_US
bordeaux.journalTransplantationen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03389929
hal.version1
hal.date.transferred2021-10-21T08:50:03Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Transplantation&amp;rft.date=2021-06-23&amp;rft.eissn=1534-6080&amp;rft.issn=1534-6080&amp;rft.au=DEWITTE,%20Antoine&amp;DEFAYE,%20Myl%C3%A8ne&amp;DAHMI,%20Anissa&amp;OUATTARA,%20Alexandre&amp;JOANNES-BOYAU,%20Olivier&amp;rft.genre=article


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