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Microglial cannabinoid type 1 receptor regulates brain inflammation in a sex-specific manner

dc.rights.licenseopenen_US
dc.contributor.authorDE MEIJ, Julia
dc.contributor.authorALFANEK, Zain
dc.contributor.authorMOREL, Lydie
dc.contributor.authorDECOEUR, Fanny
dc.contributor.authorLEYROLLE, Quentin
dc.contributor.authorPICARD, Katherine
dc.contributor.authorCARRIER, Micael
dc.contributor.authorAUBERT, Agnes
dc.contributor.authorSERE, Alexandra
dc.contributor.authorLUCAS, Celine
dc.contributor.authorLAFOREST, Gerald
dc.contributor.authorHELBLING, Jean Christophe
dc.contributor.authorTREMBLAY, Marie-Eve
dc.contributor.authorCOTA, Daniela
dc.contributor.authorMOISAN, Marie Pierre
IDREF: 060242264
dc.contributor.authorMARSICANO, Giovanni
dc.contributor.authorLAYE, Sophie
dc.contributor.authorNADJAR, Agnes
dc.date.accessioned2021-10-20T12:55:42Z
dc.date.available2021-10-20T12:55:42Z
dc.date.issued2021
dc.identifier.issn2578-5125en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112845
dc.description.abstractEnBackground: Neuroinflammation is a key feature shared by most, if not all, neuropathologies. It involves complex biological processes that act as a protective mechanism to fight against the injurious stimuli, but it can lead to tissue damage if self-perpetuating. In this context, microglia, the main cellular actor of neuroinflammation in the brain, are seen as a double-edged sword. By phagocyting neuronal debris, these cells can not only provide tissue repair but can also contribute to neuronal damage by releasing harmful substances, including inflammatory cytokines. The mechanisms guiding these apparent opposing actions are poorly known. The endocannabinoid system modulates the release of inflammatory factors such as cytokines and could represent a functional link between microglia and neuroinflammatory processes. According to transcriptomic databases and in vitro studies, microglia, the main source of cytokines in pathological conditions, express the cannabinoid type 1 receptor (CB1R). Methods: We thus developed a conditional mouse model of CB1R deletion specifically in microglia, which was subjected to an immune challenge (peripheral lipopolysaccharide injection). Results: Our results reveal that microglial CB1R differentially controls sickness behavior in males and females. Conclusion: These findings add to the comprehension of neuroinflammatory processes and might be of great interest for future studies aimed at developing therapeutic strategies for brain disorders with higher prevalence in men.
dc.language.isoENen_US
dc.subject.encytokine
dc.subject.enmicroglia
dc.subject.eninflammation
dc.subject.enCB1 receptor
dc.subject.ensickness behavior
dc.title.enMicroglial cannabinoid type 1 receptor regulates brain inflammation in a sex-specific manner
dc.typeArticle de revueen_US
dc.identifier.doi10.1089/can.2020.0170en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34591647en_US
bordeaux.journalCannabis Cannabinoid Researchen_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cannabis%20Cannabinoid%20Research&rft.date=2021&rft.eissn=2578-5125&rft.issn=2578-5125&rft.au=DE%20MEIJ,%20Julia&ALFANEK,%20Zain&MOREL,%20Lydie&DECOEUR,%20Fanny&LEYROLLE,%20Quentin&rft.genre=article


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