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Microglia modulates hippocampal synaptic transmission and sleep duration along the light/dark cycle

dc.rights.licenseopenen_US
dc.contributor.authorCORSI, Giorgio
dc.contributor.authorPICARD, Katherine
dc.contributor.authorDI CASTRO, Maria Amalia
dc.contributor.authorGAROFALO, Stefano
dc.contributor.authorTUCCI, Federico
dc.contributor.authorCHECE, Giuseppina
dc.contributor.authorDEL PERCIO, Claudio
dc.contributor.authorGOLIA, Maria Teresa
dc.contributor.authorRASPA, Marcello
dc.contributor.authorSCAVIZZI, Ferdinando
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDECOEUR, Fanny
dc.contributor.authorLAURO, Clotilde
dc.contributor.authorRIGAMONTI, Mara
dc.contributor.authorIANNELLO, Fabio
dc.contributor.authorRAGOZZINO, Davide Antonio
dc.contributor.authorRUSSO, Eleonora
dc.contributor.authorBERNARDINI, Giovanni
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorNADJAR, Agnes
dc.contributor.authorTREMBLAY, Marie-Eve
dc.contributor.authorBABILONI, Claudio
dc.contributor.authorMAGGI, Laura
dc.contributor.authorLIMATOLA, Cristina
dc.date.accessioned2021-10-20T12:31:29Z
dc.date.available2021-10-20T12:31:29Z
dc.date.issued2021
dc.identifier.issn0894-1491en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112839
dc.description.abstractEnMicroglia, the brain's resident macrophages, actively contributes to the homeostasis of cerebral parenchyma by sensing neuronal activity and supporting synaptic remodeling and plasticity. While several studies demonstrated different roles for astrocytes in sleep, the contribution of microglia in the regulation of sleep/wake cycle and in the modulation of synaptic activity in the different day phases has not been deeply investigated. Using light as a zeitgeber cue, we studied the effects of microglial depletion with the colony stimulating factor-1 receptor antagonist PLX5622 on the sleep/wake cycle and on hippocampal synaptic transmission in male mice. Our data demonstrate that almost complete microglial depletion increases the duration of NREM sleep and reduces the hippocampal excitatory neurotransmission. The fractalkine receptor CX3CR1 plays a relevant role in these effects, because cx3cr1GFP/GFP mice recapitulate what found in PLX5622-treated mice. Furthermore, during the light phase, microglia express lower levels of cx3cr1 and a reduction of cx3cr1 expression is also observed when cultured microglial cells are stimulated by ATP, a purinergic molecule released during sleep. Our findings suggest that microglia participate in the regulation of sleep, adapting their cx3cr1 expression in response to the light/dark phase, and modulating synaptic activity in a phase-dependent manner.
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.encx3cr1
dc.subject.enelectroencephalography
dc.subject.enlong-term potentiation
dc.subject.enmicroglial depletion
dc.subject.enminiature excitatory post-synaptic currents
dc.subject.ensleep
dc.subject.enspontaneous excitatory post-synaptic currents
dc.title.enMicroglia modulates hippocampal synaptic transmission and sleep duration along the light/dark cycle
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/glia.24090en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34487590en_US
bordeaux.journalGliaen_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFonds de Recherche du Québec - Santéen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDLabEx BRAINen_US
hal.identifierhal-03388499
hal.version1
hal.date.transferred2021-10-20T12:31:53Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Glia&rft.date=2021&rft.eissn=0894-1491&rft.issn=0894-1491&rft.au=CORSI,%20Giorgio&PICARD,%20Katherine&DI%20CASTRO,%20Maria%20Amalia&GAROFALO,%20Stefano&TUCCI,%20Federico&rft.genre=article


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