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Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBIYONG, Essi Fanny
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorALFOS, Serge
hal.structure.identifierUnité de recherche Mycologie et Sécurité des Aliments [MycSA]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUMETZ, Fabien
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHELBLING, Jean Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBROSSAUD, Julie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFOURY, Aline
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie Pierre
IDREF: 060242264
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
hal.structure.identifierBiothérapies des maladies génétiques et cancers
dc.contributor.authorRICHARD, Emmanuel
dc.contributor.authorPATTERSON, Elaine
dc.contributor.authorMURPHY, Kiera
dc.contributor.authorREA, Kieran
dc.contributor.authorSTANTON, Catherine
dc.contributor.authorSCHELLEKENS, Harriet
dc.contributor.authorCRYAN, John F.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPALLET, Veronique
ORCID: 0000-0002-9078-3269
IDREF: 066841763
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.date.accessioned2021-10-20T08:25:22Z
dc.date.available2021-10-20T08:25:22Z
dc.date.issued2021
dc.identifier.issn0307-0565en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112826
dc.description.abstractEnBackground: Early consumption of obesogenic diets, rich in saturated fat and added sugar, is associated with a plethora of biological dysfunctions, at both peripheral and brain levels. Obesity is also linked to decreased vitamin A bioavailability, an essential molecule for brain plasticity and memory function. Methods: Here we investigated in mice whether dietary vitamin A supplementation (VAS) could prevent some of the metabolic, microbiota, neuronal and cognitive alterations induced by obesogenic, high-fat and high-sugar diet (HFSD) exposure from weaning to adulthood, i.e. covering periadolescent period. Results: As expected, VAS was effective in enhancing peripheral vitamin A levels as well as hippocampal retinoic acid levels, the active metabolite of vitamin A, regardless of the diet. VAS attenuated HFSD-induced excessive weight gain, without affecting metabolic changes, and prevented alterations of gut microbiota ?-diversity. In HFSD-fed mice, VAS prevented recognition memory deficits but had no effect on aversive memory enhancement. Interestingly, VAS alleviated both HFSD-induced higher neuronal activation and lower glucocorticoid receptor phosphorylation in the hippocampus after training. Conclusion: Dietary VAS was protective against the deleterious effects of early obesogenic diet consumption on hippocampal function, possibly through modulation of the gut-brain axis.
dc.language.isoENen_US
dc.title.enDietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41366-020-00723-zen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33223517en_US
bordeaux.journalInternational Journal of Obesityen_US
bordeaux.page588-598en_US
bordeaux.volume45en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Obesity&rft.date=2021&rft.volume=45&rft.issue=3&rft.spage=588-598&rft.epage=588-598&rft.eissn=0307-0565&rft.issn=0307-0565&rft.au=BIYONG,%20Essi%20Fanny&ALFOS,%20Serge&DUMETZ,%20Fabien&HELBLING,%20Jean%20Christophe&AUBERT,%20Agnes&rft.genre=article


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