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Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations
dc.rights.license | open | en_US |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BIYONG, Essi Fanny | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | ALFOS, Serge | |
hal.structure.identifier | Unité de recherche Mycologie et Sécurité des Aliments [MycSA] | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | DUMETZ, Fabien | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | HELBLING, Jean Christophe | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | AUBERT, Agnes | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BROSSAUD, Julie | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | FOURY, Aline | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | MOISAN, Marie Pierre
IDREF: 060242264 | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LAYE, Sophie | |
hal.structure.identifier | Biothérapies des maladies génétiques et cancers | |
dc.contributor.author | RICHARD, Emmanuel | |
dc.contributor.author | PATTERSON, Elaine | |
dc.contributor.author | MURPHY, Kiera | |
dc.contributor.author | REA, Kieran | |
dc.contributor.author | STANTON, Catherine | |
dc.contributor.author | SCHELLEKENS, Harriet | |
dc.contributor.author | CRYAN, John F. | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | PALLET, Veronique
ORCID: 0000-0002-9078-3269 IDREF: 066841763 | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | FERREIRA, Guillaume | |
dc.date.accessioned | 2021-10-20T08:25:22Z | |
dc.date.available | 2021-10-20T08:25:22Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0307-0565 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112826 | |
dc.description.abstractEn | Background: Early consumption of obesogenic diets, rich in saturated fat and added sugar, is associated with a plethora of biological dysfunctions, at both peripheral and brain levels. Obesity is also linked to decreased vitamin A bioavailability, an essential molecule for brain plasticity and memory function. Methods: Here we investigated in mice whether dietary vitamin A supplementation (VAS) could prevent some of the metabolic, microbiota, neuronal and cognitive alterations induced by obesogenic, high-fat and high-sugar diet (HFSD) exposure from weaning to adulthood, i.e. covering periadolescent period. Results: As expected, VAS was effective in enhancing peripheral vitamin A levels as well as hippocampal retinoic acid levels, the active metabolite of vitamin A, regardless of the diet. VAS attenuated HFSD-induced excessive weight gain, without affecting metabolic changes, and prevented alterations of gut microbiota ?-diversity. In HFSD-fed mice, VAS prevented recognition memory deficits but had no effect on aversive memory enhancement. Interestingly, VAS alleviated both HFSD-induced higher neuronal activation and lower glucocorticoid receptor phosphorylation in the hippocampus after training. Conclusion: Dietary VAS was protective against the deleterious effects of early obesogenic diet consumption on hippocampal function, possibly through modulation of the gut-brain axis. | |
dc.language.iso | EN | en_US |
dc.title.en | Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s41366-020-00723-z | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 33223517 | en_US |
bordeaux.journal | International Journal of Obesity | en_US |
bordeaux.page | 588-598 | en_US |
bordeaux.volume | 45 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 3 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Obesity&rft.date=2021&rft.volume=45&rft.issue=3&rft.spage=588-598&rft.epage=588-598&rft.eissn=0307-0565&rft.issn=0307-0565&rft.au=BIYONG,%20Essi%20Fanny&ALFOS,%20Serge&DUMETZ,%20Fabien&HELBLING,%20Jean%20Christophe&AUBERT,%20Agnes&rft.genre=article |
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