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Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report

dc.rights.licenseopenen_US
dc.contributor.authorYRONDI, Antoine
dc.contributor.authorVAIVA, Guillaume
dc.contributor.authorWALTER, Michel
dc.contributor.authorD'AMATO, Thierry
dc.contributor.authorBELLIVIER, Frank
dc.contributor.authorBENNABI, Djamila
dc.contributor.authorBOUGEROL, Thierry
dc.contributor.authorCAMUS, Vincent
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDOUMY, Olivier
dc.contributor.authorGENTY, Jean-Baptiste
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorHOLTZMANN, Jerome
dc.contributor.authorHORN, Mathilde
dc.contributor.authorLANCON, Christophe
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorMARUANI, Julia
dc.contributor.authorMOIRAND, Remi
dc.contributor.authorMOLIERE, Fanny
dc.contributor.authorPETRUCCI, Jean
dc.contributor.authorRICHIERI, Raphaelle
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorSCHMITT, Laurent
dc.contributor.authorSTEPHAN, Florian
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorEL-HAGE, Wissam
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.date.accessioned2021-10-20T07:59:50Z
dc.date.available2021-10-20T07:59:50Z
dc.date.issued2021
dc.identifier.issn0022-3956en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112823
dc.description.abstractEnObjective: In addition to heredity, exposure to early-life adversity is an important predisposing risk factor of suicidal behaviour. Although the association between Childhood Trauma (CT) and suicide risk is well documented, interactions between CT and suicidal behaviour in Treatment-Resistant Depression (TRD) populations have received little coverage. This study aimed to evaluate i) association between CT and suicidal behaviour in a TRD population, and ii) the role of personality traits and impulsiveness as potential factors of mediation in these associations. Methods: Patients were recruited from a cohort of the French network of TRD expert centers. Depressive symptom severity, CT, suicidal behaviour, personality traits, and impulsiveness were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Childhood Trauma Questionnaire (CTQ), the Columbia Suicide Severity Rating Scale (CSSRS), the Structured Clinical Interview for DSM-IV, the Big Five Inventory, and the Barratt Impulsivness Scale (BIS) respectively. Results: Among the 256 patients with a baseline CTQ, in relation to suicide risk for the current depressive episode, we found an association with the total CTQ scores mediated by the intensity of the current episode in a model adjusted for age and sex (total effect: β = 0.171 ; p = 0.011, direct effect: β = 0.135 ; p = 0.043 ; indirect effect: β = 0.036 ; p = 0.048). Focusing on CT subtypes, we detected an association between suicide risk and physical neglect in a model adjusted for age and sex (β = 0.301 ; p = 0.002), without any mediation by the intensity of the current episode. There was no mediation effect from personality traits nor impulsiveness. With regards to CSSRS to assess suicidal ideation, we did not find any association with the total CTQ score and CT subtype scores. Conclusion: We report a strong association between suicidal behaviour and CT (in particular childhood physical neglect) in a TRD population.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.language.isoENen_US
dc.subject.enChildhood abuse
dc.subject.enChildhood neglect
dc.subject.enChildhood trauma
dc.subject.enDepressive disorders
dc.subject.enSuicide
dc.subject.enTreatment-resistant depression
dc.title.enChildhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jpsychires.2020.12.055en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33440292en_US
bordeaux.journalJournal of Psychiatric Researchen_US
bordeaux.page20-27en_US
bordeaux.volume135en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDAssistance Publique - Hôpitaux de Parisen_US
bordeaux.identifier.funderIDAstraZenecaen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Psychiatric%20Research&rft.date=2021&rft.volume=135&rft.spage=20-27&rft.epage=20-27&rft.eissn=0022-3956&rft.issn=0022-3956&rft.au=YRONDI,%20Antoine&VAIVA,%20Guillaume&WALTER,%20Michel&D'AMATO,%20Thierry&BELLIVIER,%20Frank&rft.genre=article


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