| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LINARD DE GUERTECHIN, Morgane | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BAILLET, Marion | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LETENNEUR, Luc | |
| dc.contributor.author | GARRIGUE, Isabelle | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | CATHELINE, Gwenaelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DARTIGUES, Jean-Francois | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PERES, Karine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.date.accessioned | 2021-10-11T09:30:46Z | |
| dc.date.available | 2021-10-11T09:30:46Z | |
| dc.date.issued | 2021-07-31 | |
| dc.identifier.issn | 2158-3188 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112716 | |
| dc.description.abstractEn | While previous studies suggest the implication of herpes simplex virus (HSV) in the onset of Alzheimer's disease (AD), no study has investigated its association with early neuroimaging markers of AD. In the Three-City and the AMI cohorts, the associations between HSV infection and (i) hippocampal volume (n = 349), (ii) white matter alterations in the parahippocampal cingulum and fornix using diffusion tensor imaging (n = 260), and (iii) incidence of AD (n = 1599) were assessed according to APOE4 status. Regardless of APOE4 status, infected subjects presented (i) significantly more microstructural alterations of the parahippocampal cingulum and fornix, (ii) lower hippocampal volumes only when their anti-HSV IgG level was in the highest tercile-reflecting possibly more frequent reactivations of the virus (p = 0.03 for subjects with a high anti-HSV IgG level while there was no association for all infected subjects, p = 0.19), and (iii) had no increased risk of developing AD. Nevertheless, among APOE4 carriers, infected subjects presented lower hippocampal volumes, although not significant (p = 0.09), and a two or three times higher risk of developing AD (adjusted Hazard ratio (aHR) = 2.72 [1.07-6.91] p = 0.04 for infected subjects and aHR = 3.87 [1.45-10.28] p = 0.007 for infected subjects with an anti-HSV IgG level in the highest tercile) while no association was found among APOE4 noncarriers. Our findings support an association between HSV infection and AD and a potential interaction between HSV status and APOE4. This reinforces the need to further investigate the infectious hypothesis of AD, especially the associated susceptibility factors and the possibility of preventive treatments. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Herpes simplex virus, early neuroimaging markers and incidence of Alzheimer's disease | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41398-021-01532-2 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34333531 | en_US |
| bordeaux.journal | Translational Psychiatry | en_US |
| bordeaux.page | 414 | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Conseil régional de Bourgogne-Franche-Comté | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Fondation Plan Alzheimer | en_US |
| bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
| bordeaux.identifier.funderID | Mutualité Sociale Agricole | en_US |
| bordeaux.identifier.funderID | Caisse Centrale de la Mutualité Sociale Agricole | en_US |
| hal.identifier | hal-03372966 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-10-11T09:30:51Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20Psychiatry&rft.date=2021-07-31&rft.volume=11&rft.issue=1&rft.spage=414&rft.epage=414&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=LINARD%20DE%20GUERTECHIN,%20Morgane&BAILLET,%20Marion&LETENNEUR,%20Luc&GARRIGUE,%20Isabelle&CATHELINE,%20Gwenaelle&rft.genre=article | |
