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Orotracheal manganese-enhanced MRI (MEMRI): An effective approach for lung tumor detection

hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBIANCHI, Andrea
hal.structure.identifierSchool of Pharmacy and Pharmaceutical Sciences and Institute of Neuroscience
dc.contributor.authorGOBBO, Oliviero
hal.structure.identifierUM Biochimie des Cancers et Biothérapies
hal.structure.identifierNano-H SAS
dc.contributor.authorDUFORT, Sandrine
hal.structure.identifierInstitut Lumière Matière [Villeurbanne] [ILM]
dc.contributor.authorSANCEY, Lucie
hal.structure.identifierInstitut Lumière Matière [Villeurbanne] [ILM]
dc.contributor.authorLUX, François
hal.structure.identifierInstitut Lumière Matière [Villeurbanne] [ILM]
dc.contributor.authorTILLEMENT, Olivier
hal.structure.identifierUM Biochimie des Cancers et Biothérapies
dc.contributor.authorCOLL, Jean-Luc
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorCRÉMILLIEUX, Yannick
dc.date.accessioned2021-10-07T16:30:21Z
dc.date.available2021-10-07T16:30:21Z
dc.date.issued2017-11
dc.identifier.issn0952-3480
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112689
dc.description.abstractEnLung cancer is a primary cause of cancer deaths worldwide. Timely detection of this pathology is necessary to delay or interrupt lung cancer progression, ultimately resulting in a possible better prognosis for the patient. In this context, magnetic resonance imaging (MRI) is especially promising. Ultra-short echo time (UTE) MRI sequences, in combination with gadolinium-based contrast agents, have indeed shown to be especially adapted to the detection of lung neoplastic lesions at submillimeter precision. Manganese-enhanced MRI (MEMRI) increasingly appears to be a possible effective alternative to gadolinium-enhanced MRI. In this work, we investigated whether low-dose MEMRI can effectively target non-small-cell lung cancer in rodents, whilst minimizing the potential toxic effect of manganese. Both systemic and orotracheal administration modalities allowed the identification of tumors of submillimeter size, as confirmed by bioluminescence imaging and histology. Equivalent tumor signal enhancements and contrast-to-noise ratios were observed with orotracheal administration using 20 times lower doses compared with the more conventional systemic route. This finding is of crucial importance as it supports the observation that higher performances of contrast agents can be obtained using an orotracheal administration route when targeting lung diseases. As a consequence, lower concentrations of contrast media can be employed, reducing the dose and potential safety issues. The non-detectable accumulation of ionic manganese in the brain and liver following orotracheal administration observed in vivo is extremely encouraging with regard to the safety of the orotracheal protocol with low-dose Mn2+ administration. To our knowledge, this is the first time that a study has clearly allowed the high-precision detection of lung tumor and its contours via the synergic employment of a strongly T1-weighted MRI UTE sequence and ionic manganese, an inexpensive contrast agent. Overall, these results support the growing interest in drug and contrast agent delivery via the airways to target and diagnose several diseases of the lungs.
dc.language.isoen
dc.publisherWiley
dc.title.enOrotracheal manganese-enhanced MRI (MEMRI): An effective approach for lung tumor detection
dc.typeArticle de revue
dc.identifier.doi10.1002/nbm.3790
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.subject.halChimie/Chimie thérapeutique
bordeaux.journalNMR in Biomedicine
bordeaux.volume30
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536*
bordeaux.issue11
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01689489
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01689489v1
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