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Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes

hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPELLETIER, Amandine
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorPÉRIOT, Olivier
dc.contributor.authorDILHARREGUY, Bixente
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorHIBA, Bassem
dc.contributor.authorBORDESSOULES, Martine
dc.contributor.authorCHANRAUD, Sandra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorALLARD, Michèle
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCATHELINE, Gwenaelle
dc.date.accessioned2021-10-07T16:29:24Z
dc.date.available2021-10-07T16:29:24Z
dc.date.issued2016-01-19
dc.identifier.issn1663-4365
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112649
dc.description.abstractEnMicrostructural changes of White Matter (WM) associated with aging have been widely described through Diffusion Tensor Imaging (DTI) parameters. In parallel, White Matter Hyperintensities (WMH) as observed on a T2-weighted MRI are extremely common in older individuals. However, few studies have investigated both phenomena conjointly. The present study investigates aging effects on DTI parameters in absence and in presence of WMH. Diffusion maps were constructed based on 21 directions DTI scans of young adults (n = 19, mean age = 33 SD = 7.4) and two age-matched groups of older adults, one presenting low-level-WMH (n = 20, mean age = 78, SD = 3.2) and one presenting high-level-WMH (n = 20, mean age = 79, SD = 5.4). Older subjects with low-level-WMH presented modifications of DTI parameters in comparison to younger subjects, fitting with the DTI pattern classically described in aging, i.e., Fractional Anisotropy (FA) decrease/Radial Diffusivity (RD) increase. Furthermore, older subjects with high-level-WMH showed higher DTI modifications in Normal Appearing White Matter (NAWM) in comparison to those with low-level-WMH. Finally, in older subjects with high-level-WMH, FA, and RD values of NAWM were associated with to WMH burden. Therefore, our findings suggest that DTI modifications and the presence of WMH would be two interdependent processes but occurring within different temporal windows. DTI changes would reflect the early phase of white matter changes and WMH would appear as a consequence of those changes.
dc.language.isoen
dc.publisherFrontiers
dc.subject.ennormal appearing white matter
dc.subject.enwhite matter hyperintensities
dc.subject.endiffusion tensor imaging
dc.subject.enaging
dc.title.enAge-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes
dc.typeArticle de revue
dc.identifier.doi10.3389/fnagi.2015.00255
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalFrontiers in Aging Neuroscience
bordeaux.volume7
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.peerReviewedoui
hal.identifierhal-02404742
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02404742v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Aging%20Neuroscience&rft.date=2016-01-19&rft.volume=7&rft.eissn=1663-4365&rft.issn=1663-4365&rft.au=PELLETIER,%20Amandine&P%C3%89RIOT,%20Olivier&DILHARREGUY,%20Bixente&HIBA,%20Bassem&BORDESSOULES,%20Martine&rft.genre=article


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