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Free-breathing 3D diffusion MRI for high-resolution hepatic metastasis characterization in small animals

hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorRIBOT, Emeline
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTROTIER, Aurelien
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorCASTETS, Charles
hal.structure.identifierCHU Bordeaux
dc.contributor.authorDALLAUDIÈRE, Benjamin
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTHIAUDIÈRE, Eric
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorFRANCONI, Jean-Michel
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMIRAUX, Sylvain
IDREF: 150967047
dc.date.accessioned2021-10-07T16:28:32Z
dc.date.available2021-10-07T16:28:32Z
dc.date.issued2016
dc.identifier.issn0262-0898
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112601
dc.description.abstractEnThe goal of this study was to develop a 3D diffusion weighted sequence for free breathing liver imaging in small animals at high magnetic field. Hepatic metastases were detected and the apparent diffusion coefficients (ADC) were measured. A 3D SE-EPI sequence was developed by (i) inserting a water-selective excitation radiofrequency pulse to suppress adipose tissue signal and (ii) bipolar diffusion gradients to decrease the sensitivity to respiration motion. Mice with hepatic metastases were imaged at 7T by applying b values from 200 to 1100 s/mm 2. 3D images with high spatial resolution (182 9 156 9 125 lm) were obtained in only 8 min 32 s. The modified DW-SE-EPI sequence allowed to obtain 3D abdominal images of healthy mice with fat SNR 2.5 times lower than without any fat suppression method and sharpness 2.8 times higher than on respiration-triggered images. Due to the high spatial resolution , the core and the periphery of disseminated hepatic metastases were differentiated at high b-values only, demonstrating the presence of edema and proliferating cells (with ADC of 2.65 9 10-3 and 1.55 9 10-3 mm 2 /s, respectively). Furthermore, these metastases were accurately distinguished from proliferating ones within the same animal at high b-values (mean ADC of 0.38 9 10-3 mm 2 /s). Metastases of less than 1.7 mm 3 diameter were detected. The new 3D SE-EPI sequence enabled to obtain diffusion information within liver metastases. In addition of intra-metastasis heterogeneity, differences in diffusion were measured between metastases within an animal. This sequence could be used to obtain diffusion information at high magnetic field.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enDiffusion
dc.subject.en3D MRI
dc.subject.en7T
dc.subject.enMetastasis
dc.subject.enliver
dc.subject.enmouse
dc.title.enFree-breathing 3D diffusion MRI for high-resolution hepatic metastasis characterization in small animals
dc.typeArticle de revue
dc.identifier.doi10.1007/s10585-015-9766-6
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalClinical and Experimental Metastasis
bordeaux.page167-178
bordeaux.volume33
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536*
bordeaux.issue2
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02404816
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02404816v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20and%20Experimental%20Metastasis&rft.date=2016&rft.volume=33&rft.issue=2&rft.spage=167-178&rft.epage=167-178&rft.eissn=0262-0898&rft.issn=0262-0898&rft.au=RIBOT,%20Emeline&TROTIER,%20Aurelien&CASTETS,%20Charles&DALLAUDI%C3%88RE,%20Benjamin&THIAUDI%C3%88RE,%20Eric&rft.genre=article


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