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The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia

dc.rights.licenseopenen_US
dc.contributor.authorDU PREEZ, Andrea
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
dc.contributor.authorHOUGHTON, Vikki
dc.contributor.authorDE LUCIA, Chiara
dc.contributor.authorLOW, Dorrain Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
ORCID: 0000-0002-7959-1610
IDREF: 08195848X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
dc.contributor.authorPALLAS, Merce
dc.contributor.authorRUIGROK, Silvie R.
dc.contributor.authorALTENDORFER, Barbara
dc.contributor.authorGONZALEZ-DOMINGUEZ, Raul
dc.contributor.authorSANCHEZ-PLA, Alex
dc.contributor.authorURPI-SARDA, Mireia
dc.contributor.authorANDRES-LACUEVA, Cristina
dc.contributor.authorAIGNER, Ludwig
dc.contributor.authorLUCASSEN, Paul J.
dc.contributor.authorKOROSI, Aniko
dc.contributor.authorMANACH, Claudine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorTHURET, Sandrine
dc.date.accessioned2021-10-01T10:27:26Z
dc.date.available2021-10-01T10:27:26Z
dc.date.issued2021-08-17
dc.identifier.issn1552-5260en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112516
dc.description.abstractEnINTRODUCTION: Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia. METHODS: Using an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their association with future CD and dementia across a 12-year period. RESULTS: Altered apoptosis and reduced hippocampal progenitor cell integrity were associated with exercise and diet and predicted subsequent CD and dementia. The effects of exercise and diet on CD specifically were mediated by apoptosis. DISCUSSION: Diet and exercise might influence neurogenesis long before the onset of CD and dementia. Alterations in HN could signify the start of the pathological process and potentially represent biomarkers for CD and dementia.
dc.description.sponsorshipIdentification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing-reversing cognitive declineen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAdult hippocampal neurogenesis
dc.subject.enCognitive decline
dc.subject.enDementia
dc.subject.enDiet
dc.subject.enExercise
dc.title.enThe serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12428en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34402599en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstituto de Salud Carlos IIIen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03361323
hal.version1
hal.date.transferred2021-10-01T10:27:33Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2021-08-17&rft.eissn=1552-5260&rft.issn=1552-5260&rft.au=DU%20PREEZ,%20Andrea&LEFEVRE%20ARBOGAST,%20Sophie&HOUGHTON,%20Vikki&DE%20LUCIA,%20Chiara&LOW,%20Dorrain%20Y.&rft.genre=article


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