dc.rights.license | open | en_US |
dc.contributor.author | BASTARD, Paul | |
dc.contributor.author | GERVAIS, Adrian | |
dc.contributor.author | LE VOYER, Tom | |
dc.contributor.author | ROSAIN, Jeremie | |
dc.contributor.author | PHILIPPOT, Quentin | |
dc.contributor.author | MANRY, Jeremy | |
dc.contributor.author | MICHAILIDIS, Eleftherios | |
dc.contributor.author | HOFFMANN, Hans-Heinrich | |
dc.contributor.author | ETO, Shohei | |
dc.contributor.author | GARCIA-PRAT, Marina | |
dc.contributor.author | BIZIEN, Lucy | |
dc.contributor.author | PARRA-MARTINEZ, Alba | |
dc.contributor.author | YANG, Rui | |
dc.contributor.author | HALJASMAGI, Liis | |
dc.contributor.author | MIGAUD, Melanie | |
dc.contributor.author | SAREKANNU, Karita | |
dc.contributor.author | MASLOVSKAJA, Julia | |
dc.contributor.author | DE PROST, Nicolas | |
dc.contributor.author | TANDJAOUI-LAMBIOTTE, Yacine | |
dc.contributor.author | LUYT, Charles-Edouard | |
dc.contributor.author | AMADOR-BORRERO, Blanca | |
dc.contributor.author | GAUDET, Alexandre | |
dc.contributor.author | POISSY, Julien | |
dc.contributor.author | MOREL, Pascal | |
dc.contributor.author | RICHARD, Pascale | |
dc.contributor.author | COGNASSE, Fabrice | |
dc.contributor.author | TROYA, Jesus | |
dc.contributor.author | TROUILLET-ASSANT, Sophie | |
dc.contributor.author | BELOT, Alexandre | |
dc.contributor.author | SAKER, Kahina | |
dc.contributor.author | GARCON, Pierre | |
dc.contributor.author | RIVIERE, Jacques G. | |
dc.contributor.author | LAGIER, Jean-Christophe | |
dc.contributor.author | GENTILE, Stephanie | |
dc.contributor.author | ROSEN, Lindsey B. | |
dc.contributor.author | SHAW, Elana | |
dc.contributor.author | MORIO, Tomohiro | |
dc.contributor.author | TANAKA, Junko | |
dc.contributor.author | DALMAU, David | |
dc.contributor.author | THARAUX, Pierre-Louis | |
dc.contributor.author | SENE, Damien | |
dc.contributor.author | STEPANIAN, Alain | |
dc.contributor.author | MEGARBANE, Bruno | |
dc.contributor.author | TRIANTAFYLLIA, Vasiliki | |
dc.contributor.author | FEKKAR, Arnaud | |
dc.contributor.author | HEATH, James R. | |
dc.contributor.author | FRANCO, Jose Luis | |
dc.contributor.author | ANAYA, Juan-Manuel | |
dc.contributor.author | SOLE-VIOLAN, Jordi | |
dc.contributor.author | IMBERTI, Luisa | |
dc.contributor.author | BIONDI, Andrea | |
dc.contributor.author | BONFANTI, Paolo | |
dc.contributor.author | CASTAGNOLI, Riccardo | |
dc.contributor.author | DELMONTE, Ottavia M. | |
dc.contributor.author | ZHANG, Yu | |
dc.contributor.author | SNOW, Andrew L. | |
dc.contributor.author | HOLLAND, Steven M. | |
dc.contributor.author | BIGGS, Catherine | |
dc.contributor.author | MONCADA-VELEZ, Marcela | |
dc.contributor.author | ARIAS, Andres Augusto | |
dc.contributor.author | LORENZO, Lazaro | |
dc.contributor.author | BOUCHERIT, Soraya | |
dc.contributor.author | COULIBALY, Boubacar | |
dc.contributor.author | ANGLICHEAU, Dany | |
dc.contributor.author | PLANAS, Anna M. | |
dc.contributor.author | HAERYNCK, Filomeen | |
dc.contributor.author | DUVLIS, Sotirija | |
dc.contributor.author | NUSSBAUM, Robert L. | |
dc.contributor.author | OZCELIK, Tayfun | |
dc.contributor.author | KELES, Seygi | |
dc.contributor.author | BOUSFIHA, Ahmed A. | |
dc.contributor.author | EL BAKKOURI, Jalila | |
dc.contributor.author | RAMIREZ-SANTANA, Carolina | |
dc.contributor.author | PAUL, Stephane | |
dc.contributor.author | PAN-HAMMARSTROM, Qiang | |
dc.contributor.author | HAMMARSTROM, Lennart | |
dc.contributor.author | DUPONT, Annabelle | |
dc.contributor.author | KUROLAP, Alina | |
dc.contributor.author | METZ, Christine N. | |
dc.contributor.author | AIUTI, Alessandro | |
dc.contributor.author | CASARI, Giorgio | |
dc.contributor.author | LAMPASONA, Vito | |
dc.contributor.author | CICERI, Fabio | |
dc.contributor.author | BARREIROS, Lucile A. | |
dc.contributor.author | DOMINGUEZ-GARRIDO, Elena | |
dc.contributor.author | VIDIGAL, Mateus | |
dc.contributor.author | ZATZ, Mayana | |
dc.contributor.author | VAN DE BEEK, Diederik | |
dc.contributor.author | SAHANIC, Sabina | |
dc.contributor.author | TANCEVSKI, Ivan | |
dc.contributor.author | STEPANOVSKYY, Yurii | |
dc.contributor.author | BOYARCHUK, Oksana | |
dc.contributor.author | NUKUI, Yoko | |
dc.contributor.author | TSUMURA, Miyuki | |
dc.contributor.author | VIDAUR, Loreto | |
dc.contributor.author | TANGYE, Stuart G. | |
dc.contributor.author | BURREL, Sonia | |
dc.contributor.author | DUFFY, Darragh | |
dc.contributor.author | QUINTANA-MURCI, Lluis | |
dc.contributor.author | KLOCPERK, Adam | |
dc.contributor.author | KANN, Nelli Y. | |
dc.contributor.author | SHCHERBINA, Anna | |
dc.contributor.author | LAU, Yu-Lung | |
dc.contributor.author | LEUNG, Daniel | |
dc.contributor.author | COULONGEAT, Matthieu | |
dc.contributor.author | MARLET, Julien | |
dc.contributor.author | KONING, Rutger | |
dc.contributor.author | REYES, Luis Felipe | |
dc.contributor.author | CHAUVINEAU-GRENIER, Angelique | |
dc.contributor.author | VENET, Fabienne | |
dc.contributor.author | MONNERET, Guillaume | |
dc.contributor.author | NUSSENZWEIG, Michel C. | |
dc.contributor.author | ARRESTIER, Romain | |
dc.contributor.author | BOUDHABHAY, Idris | |
dc.contributor.author | BARIS-FELDMAN, Hagit | |
dc.contributor.author | HAGIN, David | |
dc.contributor.author | WAUTERS, Joost | |
dc.contributor.author | MEYTS, Isabelle | |
dc.contributor.author | DYER, Adam H. | |
dc.contributor.author | KENNELLY, Sean P. | |
dc.contributor.author | BOURKE, Nollaig M. | |
dc.contributor.author | HALWANI, Rabih | |
dc.contributor.author | SHARIF-ASKARI, Narjes Saheb | |
dc.contributor.author | DORGHAM, Karim | |
dc.contributor.author | SALLETTE, Jerome | |
dc.contributor.author | SEDKAOUI, Souad Mehlal | |
dc.contributor.author | ALKHATER, Suzan | |
dc.contributor.author | RIGO-BONNIN, Raul | |
dc.contributor.author | MORANDEIRA, Francisco | |
dc.contributor.author | ROUSSEL, Lucie | |
dc.contributor.author | VINH, Donald C. | |
dc.contributor.author | OSTROWSKI, Sisse Rye | |
dc.contributor.author | CONDINO-NETO, Antonio | |
dc.contributor.author | PRANDO, Carolina | |
dc.contributor.author | BONRADENKO, Anastasiia | |
dc.contributor.author | SPAAN, Andras N. | |
dc.contributor.author | GILARDIN, Laurent | |
dc.contributor.author | FELLAY, Jacques | |
dc.contributor.author | LYONNET, Stanislas | |
dc.contributor.author | BILGUVAR, Kaya | |
dc.contributor.author | LIFTON, Richard P. | |
dc.contributor.author | MANE, Shrikant | |
dc.contributor.author | LAB, Hgid | |
dc.contributor.author | CLINICIANS, Covid | |
dc.contributor.author | CLINICIANS, Covid-Storm | |
dc.contributor.author | GROUP, Niaid Immune Response To COVID | |
dc.contributor.author | GROUP, Nh-Covair Study | |
dc.contributor.author | DANISH, Chge | |
dc.contributor.author | DANISH BLOOD DONOR, Study | |
dc.contributor.author | ST. JAMES'S, Hospital | |
dc.contributor.author | GROUP, Sars CoV2 Interest | |
dc.contributor.author | FRENCH, Covid Cohort Study Group | |
dc.contributor.author | IMAGINE, Covid-Group | |
dc.contributor.author | MILIEU INTERIEUR, Consortium | |
dc.contributor.author | CO, V. Contact Cohort | |
dc.contributor.author | AMSTERDAM, U. M. C. Covid | |
dc.contributor.author | BIOBANK, Investigators | |
dc.contributor.author | EFFORT, Covid Human Genetic | |
dc.contributor.author | COHORT, Constances | |
dc.contributor.author | STUDY, C. Dijon | |
dc.contributor.author | CERBA, Health-Care | |
dc.contributor.author | ETABLISSEMENT DU SANG STUDY, Group | |
dc.contributor.author | ANDERSON, Mark S. | |
dc.contributor.author | BOISSON, Bertrand | |
dc.contributor.author | BEZIAT, Vivien | |
dc.contributor.author | ZHANG, Shen-Ying | |
dc.contributor.author | VANDREAKOS, Evangelos | |
dc.contributor.author | HERMINE, Olivier | |
dc.contributor.author | PUJOL, Aurora | |
dc.contributor.author | PETERSON, Part | |
dc.contributor.author | MOGENSEN, Trine H. | |
dc.contributor.author | ROWEN, Lee | |
dc.contributor.author | MOND, James | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DEBETTE, Stephanie | |
dc.contributor.author | DE LAMBALLERIE, Xavier | |
dc.contributor.author | DUVAL, Xavier | |
dc.contributor.author | MENTRE, France | |
dc.contributor.author | ZINS, Marie | |
dc.contributor.author | SOLER-PALACIN, Pere | |
dc.contributor.author | COLOBRAN, Roger | |
dc.contributor.author | GOROCHOV, Guy | |
dc.contributor.author | SOLANICH, Xavier | |
dc.contributor.author | SUSEN, Sophie | |
dc.contributor.author | MARTINEZ-PICADO, Javier | |
dc.contributor.author | RAOULT, Didier | |
dc.contributor.author | VASSE, Marc | |
dc.contributor.author | GREGERSEN, Peter K. | |
dc.contributor.author | PIEMONTI, Lorenzo | |
dc.contributor.author | RODRIGUEZ-GALLEGO, Carlos | |
dc.contributor.author | NOTARANGELO, Luigi D. | |
dc.contributor.author | SU, Helen C. | |
dc.contributor.author | KISAND, Kai | |
dc.contributor.author | OKADA, Satoshi | |
dc.contributor.author | PUEL, Anne | |
dc.contributor.author | JOUANGUY, Emmanuelle | |
dc.contributor.author | RICE, Charles M. | |
dc.contributor.author | TIBERGHIEN, Pierre | |
dc.contributor.author | ZHANG, Qian | |
dc.contributor.author | COBAT, Aurelie | |
dc.contributor.author | ABEL, Laurent | |
dc.contributor.author | CASANOVA, Jean-Laurent | |
dc.date.accessioned | 2021-09-29T13:59:29Z | |
dc.date.available | 2021-09-29T13:59:29Z | |
dc.date.issued | 2021-08-19 | |
dc.identifier.issn | 2470-9468 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112480 | |
dc.description.abstractEn | Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases. | |
dc.description.sponsorship | Identification des défauts monogéniques de l'immunité responsables des formes sévères de COVID-19 chez les patients précédemment en bonne santé | en_US |
dc.description.sponsorship | Analyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévères | en_US |
dc.description.sponsorship | Bases génétiques et immunologiques des auto-anticorps contre les interférons de type I prédisposant aux formes sévères de COVID-19. | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title.en | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1126/sciimmunol.abl4340 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 34413139 | en_US |
dc.description.sponsorshipEurope | Program Initiative d’Excellence | en_US |
bordeaux.journal | Science Immunology | en_US |
bordeaux.volume | 6 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 62 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | VINTAGE | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Howard Hughes Medical Institute | en_US |
bordeaux.identifier.funderID | Rockefeller University | en_US |
bordeaux.identifier.funderID | St. Giles Foundation | en_US |
bordeaux.identifier.funderID | National Human Genome Research Institute | en_US |
bordeaux.identifier.funderID | Meyer Foundation | en_US |
bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Fondation du Souffle | en_US |
bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Ministère des Solidarités et de la Santé | en_US |
bordeaux.identifier.funderID | European Commission | en_US |
bordeaux.identifier.funderID | Sorbonne Université | en_US |
bordeaux.identifier.funderID | Université de Bordeaux | en_US |
bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.identifier.funderID | Conseil régional de Bourgogne-Franche-Comté | en_US |
bordeaux.identifier.funderID | Fondation de France | en_US |
bordeaux.identifier.funderID | National Cancer Institute | en_US |
bordeaux.identifier.funderID | Instituto de Salud Carlos III | en_US |
bordeaux.identifier.funderID | European Regional Development Fund | en_US |
bordeaux.identifier.funderID | Fundación DISA | en_US |
bordeaux.identifier.funderID | Ministero della Salute | en_US |
bordeaux.identifier.funderID | Jeffrey Modell Foundation | en_US |
bordeaux.identifier.funderID | Meath Foundation | en_US |
hal.identifier | hal-03358792 | |
hal.version | 1 | |
hal.date.transferred | 2021-09-29T13:59:50Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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