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Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge

dc.rights.licenseopenen_US
dc.contributor.authorTOGNINI, Paola
dc.contributor.authorSAMAD, Muntaha
dc.contributor.authorKINOUCHI, Kenichiro
dc.contributor.authorLIU, Yu
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHELBLING, Jean Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie Pierre
dc.contributor.authorECKEL-MAHAN, Kristin
dc.contributor.authorBALDI, Pierre
dc.contributor.authorSASSONE-CORSI, Paolo
dc.date.accessioned2021-09-28T11:35:36Z
dc.date.available2021-09-28T11:35:36Z
dc.date.issued2020-11
dc.identifier.issn0027-8424en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112467
dc.description.abstractEnSignificance : Nutrition and the body clock are deeply intertwined, both impinging on our physiological health. Food composition can dramatically rewire peripheral clock metabolism; however, whether food challenges can impact circadian metabolism of the master clock in the suprachiasmatic nucleus (SCN) or other brain areas has not been fully explored. Here we analyzed the complete diurnal metabolome of the SCN and medial prefrontal cortex (mPFC) in mice fed a balanced diet or a high-fat diet (HFD). Strikingly, our data reveal unexpected daily rhythmicity in both SCN and mPFC metabolites that is significantly impacted by HFD in a region-specific manner. Our findings unveil an unsuspected sensitivity of brain clocks to nutrition. Abstract : Food is a powerful entrainment cue for circadian clocks in peripheral tissues, and changes in the composition of nutrients have been demonstrated to metabolically reprogram peripheral clocks. However, how food challenges may influence circadian metabolism of the master clock in the suprachiasmatic nucleus (SCN) or in other brain areas is poorly understood. Using high-throughput metabolomics, we studied the circadian metabolome profiles of the SCN and medial prefrontal cortex (mPFC) in lean mice compared with mice challenged with a high-fat diet (HFD). Both the mPFC and the SCN displayed a robust cyclic metabolism, with a strikingly high sensitivity to HFD perturbation in an area-specific manner. The phase and amplitude of oscillations were drastically different between the SCN and mPFC, and the metabolic pathways impacted by HFD were remarkably region-dependent. Furthermore, HFD induced a significant increase in the number of cycling metabolites exclusively in the SCN, revealing an unsuspected susceptibility of the master clock to food stress.
dc.language.isoENen_US
dc.subject.enHigh-fat diet
dc.subject.enPrefrontal cortex
dc.subject.enCircadian clock
dc.subject.enMetabolome reorganization
dc.subject.enSuprachiasmatic nucleus
dc.title.enReshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge
dc.typeArticle de revueen_US
dc.identifier.doi10.1073/pnas.2016589117en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33172990en_US
bordeaux.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
bordeaux.page29904-29913en_US
bordeaux.volume117en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue47en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDNovo Nordisken_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America&rft.date=2020-11&rft.volume=117&rft.issue=47&rft.spage=29904-29913&rft.epage=29904-29913&rft.eissn=0027-8424&rft.issn=0027-8424&rft.au=TOGNINI,%20Paola&SAMAD,%20Muntaha&KINOUCHI,%20Kenichiro&LIU,%20Yu&HELBLING,%20Jean%20Christophe&rft.genre=article


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