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Corticosteroid-binding globulin deficiency specifically impairs contextual and recognition memory consolidation in male mice

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA DE MEDEIROS, Gabriela
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAFENETRE, Pauline
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJANTHAKHIN, Yootana
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCERPA, Juan-Carlos
dc.contributor.authorZHANG, Chun-Lei
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMEHTA, Marishka M.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMORTESSAGNE, Pierre
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHELBLING, Jean Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie Pierre
IDREF: 060242264
dc.date.accessioned2021-09-28T10:24:34Z
dc.date.available2021-09-28T10:24:34Z
dc.date.issued2019
dc.identifier.issn0028-3835en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112464
dc.description.abstractEnBackground/Aims: Glucocorticoids are essential in modulating memory processes of emotionally arousing experiences and we have shown that corticosteroid-binding globulin (CBG) influences glucocorticoid delivery to the brain. Here, we investigated the role of CBG in contextual and recognition long-term memory according to stress intensity. Method: We used adult male mice totally deficient in CBG (Cbg KO) or brain-specific Cbg KO (Cbg(Camk) KO) to examine their performance in contextual fear conditioning (CFC) and au-ditory fear conditioning, both at short (1 h) and long-term (24 h). Long-term memory in Cbg KO was further analyzed in conditioned odor aversion and in novel object recognition task (NORT) with different paradigms, that is, with and without prior habituation to the context, with a mild or strong stressor applied during consolidation. In the NORT experiments, total and free glucocorticoid levels were measured during consolidation. Results: Impaired memory was observed in the Cbg KO but not in the Cbg(Camk) KO in the CFC and the NORT without habituation when tested 24 h later. However, Cbg KO displayed normal behavior in the NORT with previous habituation and in the NORT with a mild stressor. In condition of the NORT with a strong stressor, Cbg KO retained good 24 h memory performance while controls were impaired. Total and free glucocorticoids levels were always higher in controls than in Cbg KO except in NORT with mild stressor where free glucocorticoids were equivalent to controls. Conclusions: These data indicate that circulating but not brain CBG influences contextual and recognition long-term memory in relation with glucocorticoid levels.
dc.language.isoENen_US
dc.subject.enGlucocorticoids
dc.subject.enMemory
dc.subject.enStress
dc.subject.enHippocampus
dc.subject.enTranscortin
dc.title.enCorticosteroid-binding globulin deficiency specifically impairs contextual and recognition memory consolidation in male mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1159/000499827en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed30904918en_US
bordeaux.journalNeuroendocrinologyen_US
bordeaux.page322-332en_US
bordeaux.volume109en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuroendocrinology&rft.date=2019&rft.volume=109&rft.issue=4&rft.spage=322-332&rft.epage=322-332&rft.eissn=0028-3835&rft.issn=0028-3835&rft.au=FERREIRA%20DE%20MEDEIROS,%20Gabriela&LAFENETRE,%20Pauline&JANTHAKHIN,%20Yootana&CERPA,%20Juan-Carlos&ZHANG,%20Chun-Lei&rft.genre=article


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