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Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour

dc.rights.licenseopenen_US
dc.contributor.authorMARTY, Virginie
dc.contributor.authorLABIALLE, Stephane
dc.contributor.authorBORTOLIN-CAVAILLE, Marie-Line
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA DE MEDEIROS, Gabriela
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie Pierre
IDREF: 060242264
dc.contributor.authorFLORIAN, Cedrick
dc.contributor.authorCAVAILLE, Jerome
dc.date.accessioned2021-09-28T09:19:08Z
dc.date.available2021-09-28T09:19:08Z
dc.date.issued2016-02
dc.identifier.issn0964-6906en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112455
dc.description.abstractEnThe brain-specific miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 domain is implicated in several aspects of brain development and function, particularly in fine-tuning the dendritic outgrowth and spine remodelling of hippocampal neurons. Whether it might influence behaviour and memory-related processes has not yet been explored at the whole organism level. We previously reported that constitutive deletion of the miR-379/miR-410 gene cluster affects metabolic adaptation in neonatal mice. Here, we examined the role of this cluster in adult brain functions by subjecting mice with the constitutive deletion to a battery of behavioural and cognitive tests. We found that the lack of miR-379/miR-410 expression is associated with abnormal emotional responses, as demonstrated by increased anxiety-related behaviour in unfamiliar environments. In contrast, spontaneous exploration, general locomotion, mood levels and sociability remained unaltered. Surprisingly, miR-379/miR-410-deficient mice also showed normal learning and spatial (or contextual) memory abilities in hippocampus-dependent tasks involving neuronal plasticity. Taken together, the imprinted miR-379/miR-410 gene cluster thus emerges as a novel regulator of the two main post-natal physiological processes previously associated with imprinted, protein-coding genes: behaviour and energy homeostasis.
dc.description.sponsorshipBiological functions of imprinted microRNA genes - ANR-07-JCJC-0101en_US
dc.language.isoENen_US
dc.subject.enAnxiety
dc.subject.enAdult
dc.subject.enGenes
dc.subject.enHippocampus
dc.subject.enBrain
dc.subject.enMemory
dc.subject.enMice
dc.subject.enGene clusters
dc.title.enDeletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/hmg/ddv510en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed26744330en_US
bordeaux.journalHuman Molecular Geneticsen_US
bordeaux.page728-739en_US
bordeaux.volume25en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Human%20Molecular%20Genetics&rft.date=2016-02&rft.volume=25&rft.issue=4&rft.spage=728-739&rft.epage=728-739&rft.eissn=0964-6906&rft.issn=0964-6906&rft.au=MARTY,%20Virginie&LABIALLE,%20Stephane&BORTOLIN-CAVAILLE,%20Marie-Line&FERREIRA%20DE%20MEDEIROS,%20Gabriela&MOISAN,%20Marie%20Pierre&rft.genre=article


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