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CB1 Receptors in the anterior piriform cortex control odor preference memory

dc.rights.licenseopenen_US
dc.contributor.authorTERRAL, Geoffrey
dc.contributor.authorBUSQUETS-GARCIA, Arnau
dc.contributor.authorVARILH, Marjorie
dc.contributor.authorACHICALLENDE, Svein
dc.contributor.authorCANNICH, Astrid
dc.contributor.authorBELLOCCHIO, Luigi
dc.contributor.authorBONILLA-DEL RIO, Itziar
dc.contributor.authorMASSA, Federico
dc.contributor.authorPUENTE, Nagore
dc.contributor.authorSORIA-GOMEZ, Edgar
dc.contributor.authorGRANDES, Pedro
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.date.accessioned2021-09-27T12:47:25Z
dc.date.available2021-09-27T12:47:25Z
dc.date.issued2019
dc.identifier.issn0960-9822en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112415
dc.description.abstractEnThe retrieval of odor-related memories shapes animal behavior. The anterior piriform cortex (aPC) is the largest part of the olfactory cortex, and it plays important roles in olfactory processing and memory. However, it is still unclear whether specific cellular mechanisms in the aPC control olfactory memory, depending on the appetitive or aversive nature of the stimuli involved. Cannabinoid-type 1 (CB1) receptors are present in the aPC (aPC-CB1), but their potential impact on olfactory memory was never explored. Here, we used a combination of behavioral, genetic, anatomical, and electrophysiological approaches to characterize the functions of aPC-CB1 receptors in the regulation of appetitive and aversive olfactory memory. Pharmacological blockade or genetic deletion of aPC-CB1 receptors specifically impaired the retrieval of conditioned odor preference (COP). Interestingly, expression of conditioned odor aversion (COA) was unaffected by local CB1 receptor blockade, indicating that the role of aPC endocannabinoid signaling is selective for retrieval of appetitive memory. Anatomical investigations revealed that CB1 receptors are highly expressed on aPC GABAergic interneurons, and ex vivo electrophysiological recordings showed that their pharmacological activation reduces miniature inhibitory post-synaptic currents (mIPSCs) onto aPC semilunar (SL), but not pyramidal principal neurons. COP retrieval, but not COA, was associated with a specific CB1-receptor-dependent decrease of mIPSCs in SL cells. Altogether, these data indicate that aPC-CB1 receptor-dependent mechanisms physiologically control the retrieval of olfactory memory, depending on odor valence and engaging modulation of local inhibitory transmission.
dc.description.sponsorshipDissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes.en_US
dc.description.sponsorshipReprésentation sensorielle lors d'états psychotiquesen_US
dc.description.sponsorshipRecepteurs aux cannabinoides dans le codage visuel cortical - ANR-18-CE16-0001en_US
dc.description.sponsorshipRecepteurs aux cannabinoides dans le codage visuel cortical - ANR-18-CE16-0001en_US
dc.language.isoENen_US
dc.subject.enAnterior piriform cortex
dc.subject.enCB1 receptors
dc.subject.enConditioned odor preference
dc.subject.enConditioned odor aversion
dc.subject.enNeuroanatomy
dc.subject.enMiniature inhibitory currents
dc.subject.enmIPSCs
dc.subject.enSemilunar neurons
dc.subject.enPyramidal neurons
dc.title.enCB1 Receptors in the anterior piriform cortex control odor preference memory
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cub.2019.06.041en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed31327715en_US
dc.description.sponsorshipEuropeNeurocircuitry of endocannabinoid regulation of food intakeen_US
dc.description.sponsorshipEuropeDevelopment of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromesen_US
bordeaux.journalCurrent Biology - CBen_US
bordeaux.page2455-2464en_US
bordeaux.volume29en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue15en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDLabEx BRAINen_US
bordeaux.identifier.funderIDEuropean Research Councilen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Biology%20-%20CB&rft.date=2019&rft.volume=29&rft.issue=15&rft.spage=2455-2464&rft.epage=2455-2464&rft.eissn=0960-9822&rft.issn=0960-9822&rft.au=TERRAL,%20Geoffrey&BUSQUETS-GARCIA,%20Arnau&VARILH,%20Marjorie&ACHICALLENDE,%20Svein&CANNICH,%20Astrid&rft.genre=article


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