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Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats
| dc.rights.license | open | en_US |
| dc.contributor.author | LODS, Marie | |
| dc.contributor.author | PACARY, Emilie | |
| dc.contributor.author | MAZIER, Wilfrid | |
| dc.contributor.author | FARRUGIA, Fanny | |
| dc.contributor.author | MORTESSAGNE, Pierre | |
| dc.contributor.author | MASACHS, Nuria | |
| dc.contributor.author | CHARRIER, Vanessa | |
| dc.contributor.author | MASSA, Federico | |
| dc.contributor.author | COTA, Daniela | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| dc.contributor.author | ABROUS, Nora | |
| dc.contributor.author | TRONEL, Sophie | |
| dc.date.accessioned | 2021-09-27T09:41:53Z | |
| dc.date.available | 2021-09-27T09:41:53Z | |
| dc.date.issued | 2021 | |
| dc.identifier.issn | 2041-1723 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112403 | |
| dc.description.abstractEn | Memory reconsolidation, the process by which memories are again stabilized after being reactivated, has strengthened the idea that memory stabilization is a highly plastic process. To date, the molecular and cellular bases of reconsolidation have been extensively investigated particularly within the hippocampus. However, the role of adult neurogenesis in memory reconsolidation is unclear. Here, we combined functional imaging, retroviral and chemogenetic approaches in rats to tag and manipulate different populations of rat adult-born neurons. We find that both mature and immature adult-born neurons are activated by remote memory retrieval. However, only specific silencing of the adult-born neurons immature during learning impairs remote memory retrieval-induced reconsolidation. Hence, our findings show that adult-born neurons immature during learning are required for the maintenance and update of remote memory reconsolidation. | |
| dc.description.sponsorship | Rôle de la neurogénèse hippocampique dans la reconsolidation de la mémoire - ANR-16-CE37-0018 | en_US |
| dc.description.sponsorship | Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes. - ANR-13-BSV4-0006 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41467-021-22069-4 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33741954 | en_US |
| bordeaux.journal | Nature Communications | en_US |
| bordeaux.volume | 12 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | INSERM | |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2021&rft.volume=12&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=LODS,%20Marie&PACARY,%20Emilie&MAZIER,%20Wilfrid&FARRUGIA,%20Fanny&MORTESSAGNE,%20Pierre&rft.genre=article |
