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Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTHOMAZEAU, Aurore
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X
IDREF: 156530244
dc.contributor.authorMANZONI, Olivier
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
dc.date.accessioned2021-09-23T10:16:31Z
dc.date.available2021-09-23T10:16:31Z
dc.date.issued2016-11
dc.identifier.issn1047-3211en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112349
dc.description.abstractEnMaternal n-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid, is critical during perinatal brain development. How early postnatal n-3 PUFA deficiency impacts on hippocampal synaptic plasticity is mostly unknown. Here we compared activity-dependent plasticity at excitatory and inhibitory synapses in the CA1 region of the hippocampus in weaned pups whose mothers were fed with an n-3 PUFA-balanced or n-3 PUFA-deficient diet. Normally, endogenous cannabinoids (eCB) produced by the post-synapse dually control network activity by mediating the long-term depression of inhibitory inputs (iLTD) and positively gating NMDAR-dependent long-term potentiation (LTP) of excitatory inputs. We found that both iLTD and LTP were impaired in n-3 PUFA-deficient mice. Pharmacological dissection of the underlying mechanism revealed that impairment of NMDAR-dependent LTP was causally linked to and attributable to the ablation of eCB-mediated iLTD and associated to disinhibitory gating of excitatory synapses. The data shed new light on how n-3 PUFAs shape synaptic activity in the hippocampus and provide a new synaptic substrate to the cognitive impairments associated with perinatal n-3 deficiency.
dc.language.isoENen_US
dc.subject.eniLTD
dc.subject.enn-3 PUFA
dc.subject.enEndocannabinoid
dc.subject.enHippocampus
dc.subject.enSynaptic plasticity
dc.title.enNutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cercor/bhw052en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed26946127en_US
dc.description.sponsorshipEuropeFP7-267196-MSCA-COFUND-AgreenSkillsen_US
bordeaux.journalCerebral Cortexen_US
bordeaux.page2571-2579en_US
bordeaux.volume27en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDAgreenSkillsen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2016-11&rft.volume=27&rft.issue=4&rft.spage=2571-2579&rft.epage=2571-2579&rft.eissn=1047-3211&rft.issn=1047-3211&rft.au=THOMAZEAU,%20Aurore&BOSCH%20BOUJU,%20Clementine&MANZONI,%20Olivier&LAYE,%20Sophie&rft.genre=article


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