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Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDECOEUR, Fanny
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBENMAMAR-BADEL, Anouk
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEYROLLE, Quentin
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPERSILLET, Marine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorNADJAR, Agnes
dc.date.accessioned2021-09-22T15:25:13Z
dc.date.available2021-09-22T15:25:13Z
dc.date.issued2020-03
dc.identifier.issn0889-1591en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112342
dc.description.abstractEnEssential polyunsaturated fatty acids (PUFA) from the n-3 and n-6 series constitute the building blocks of brain cell membranes where they regulate most aspects of cell physiology. They are either biosynthesized from their dietary precursors or can be directly sourced from the diet. An overall increase in the dietary n-6/n-3 PUFA ratio, as observed in the Western diet, leads to reduced n-3 PUFAs in tissues that include the brain. Some clinical studies have shown a positive correlation between dietary n-3 PUFA intake and sleep quantity, yet evidence is still sparse. We here used a preclinical model of dietary n-3 PUFA deficiency to assess the precise relationship between dietary PUFA intake and sleep/wake activity. Using electroencephalography (EEG)/electromyography (EMG) recordings on n-3 PUFA deficient or sufficient mice, we showed that dietary PUFA deficiency affects the architecture of sleep-wake activity and the oscillatory activity of cortical neurons during sleep. In a second part of the study, and since PUFAs are a potent modulator of inflammation, we assessed the effect of dietary n-3 PUFA deficiency on the sleep response to an inflammatory stimulus known to modulate sleep/wake activity. We injected mice with the endotoxin lipopolysaccharide (LPS) and quantified the sleep response across the following 12 h. Our results revealed that n-3 PUFA deficiency affects the sleep response in basal condition and after a peripheral immune challenge. More studies are now required aimed at deciphering the molecular mechanisms underlying the intimate relationship between n-3 PUFAs and sleep/wake activity.
dc.language.isoENen_US
dc.subject.enDHA
dc.subject.enEEG
dc.subject.enInflammation
dc.subject.enLPS
dc.subject.enOmega-3
dc.subject.enSleep
dc.subject.enSlow wave activity
dc.title.enDietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbi.2019.05.016en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed31100369en_US
dc.description.sponsorshipEuropeProgram Initiative d’Excellenceen_US
bordeaux.journalBrain, Behavior, and Immunityen_US
bordeaux.page162-169en_US
bordeaux.volume85en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDLabEx BRAINen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDÉcole Normale Supérieureen_US
bordeaux.identifier.funderIDConseil Régional, Île-de-Franceen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior,%20and%20Immunity&rft.date=2020-03&rft.volume=85&rft.spage=162-169&rft.epage=162-169&rft.eissn=0889-1591&rft.issn=0889-1591&rft.au=DECOEUR,%20Fanny&BENMAMAR-BADEL,%20Anouk&LEYROLLE,%20Quentin&PERSILLET,%20Marine&LAYE,%20Sophie&rft.genre=article


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