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Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorRINCEL, Marion
dc.contributor.authorOLIER, Maiwenn
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMINNI, Amandine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMONCHAUX DE OLIVEIRA, Camille
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMATIME, Yann
dc.contributor.authorGAULTIER, Eric
dc.contributor.authorGRIT, Isabelle I.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHELBLING, Jean Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCOSTA, Anna-Maria
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEPINAY, Amandine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie Pierre
IDREF: 060242264
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
dc.contributor.authorFERRIER, Laurent
dc.contributor.authorPARNET, Patricia
dc.contributor.authorTHEODOROU, Vassilia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
dc.date.accessioned2021-09-22T15:10:36Z
dc.date.available2021-09-22T15:10:36Z
dc.date.issued2019
dc.identifier.issn0033-3158 (Print) 1432-2072 (Online)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112341
dc.description.abstractEnIntestinal permeability plays an important role in gut-brain axis communication. Recent studies indicate that intestinal permeability increases in neonate pups during maternal separation (MS). The present study aims to determine whether pharmacological inhibition of myosin light chain kinase (MLCK), which regulates tight junction contraction and controls intestinal permeability, in stressed neonates, protects against the long-term effects of MS. Male Wistar rats were exposed to MS (3 h per day from post-natal day (PND)2 to PND14) or left undisturbed and received daily intraperitoneal injection of a MLCK inhibitor (ML-7, 5 mg/kg) or vehicle during the same period. At adulthood, emotional behaviors, corticosterone response to stress, and gut microbiota composition were analyzed. ML-7 restored gut barrier function in MS rats specifically during the neonatal period. Remarkably, ML-7 prevented MS-induced sexual reward-seeking impairment and reversed the alteration of corticosterone response to stress at adulthood. The effects of ML-7 were accompanied by the normalization of the abundance of members of Lachnospiraceae, Clostridiales, Desulfovibrio, Bacteroidales, Enterorhabdus, and Bifidobacterium in the feces of MS rats at adulthood. Altogether, our work suggests that improvement of intestinal barrier defects during development may alleviate some of the long-term effects of early-life stress and provides new insight on brain-gut axis communication in a context of stress.
dc.language.isoENen_US
dc.subject.en16S sequencing
dc.subject.enAnimal models
dc.subject.enBlood-brain barrier
dc.subject.enDepression
dc.subject.enEarly-life stress
dc.subject.enFemale urine sniffing test
dc.subject.enIntestinal barrier
dc.subject.enIntestinal permeability
dc.subject.enIrritable bowel syndrome
dc.subject.enMyosin light chain kinase
dc.title.enPharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00213-019-05252-wen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalPsychopharmacologyen_US
bordeaux.page1583-1596en_US
bordeaux.volume236en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDDepartement Alimentation Humaine, Institut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychopharmacology&rft.date=2019&rft.volume=236&rft.issue=5&rft.spage=1583-1596&rft.epage=1583-1596&rft.eissn=0033-3158%20(Print)%201432-2072%20(Online)&rft.issn=0033-3158%20(Print)%201432-2072%20(Online)&rft.au=RINCEL,%20Marion&OLIER,%20Maiwenn&MINNI,%20Amandine&MONCHAUX%20DE%20OLIVEIRA,%20Camille&MATIME,%20Yann&rft.genre=article


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