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Protracted motivational dopamine-related deficits following adolescence sugar overconsumption

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorNANEIX, Fabien
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDARLOT, Florence
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDE SMEDT-PEYRUSSE, Veronique
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorPAPE, Jean-Remi
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOUTUREAU, Etienne
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCADOR, Martine
dc.date.accessioned2021-09-22T14:05:16Z
dc.date.available2021-09-22T14:05:16Z
dc.date.issued2018
dc.identifier.issn0028-3908en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112331
dc.description.abstractEnAdolescence represents a critical period characterized by major neurobiological changes. Chronic stimulation of the reward system during adolescence might constitute an important factor of vulnerability to pathological development. Increasing evidences suggest that adolescent overconsumption of sweet palatable foods impact reward-based processes. However, the neurobiological bases of these deficits remain poorly understood. Previous studies have demonstrated motivational deficits for palatable foods after sweet diet exposure during adolescence that might involve the dopamine (DA) system, a central actor in incentive processes. In the present study, the impact of adolescent sugar overconsumption on the sensitivity of the DA system was tested using pharmacological (Experiment 1) and receptor expression approaches (Experiment 2). Adolescent rats received free and continuous access to 5% sucrose solution from post-natal day 30-46. At adulthood, the functionality of the DA system in motivational processes was tested using systemic injections of specific DA receptors D1R or D2R agonists and antagonists during a motivation-dependent progressive ratio task (Experiment 1). Sucrose-exposed rats showed a lower motivation for saccharin and a decreased sensitivity to the effects of both D1R and D2R stimulation and blockade. In Experiment 2, Sucrose-exposed animals presented a lower expression of both D1R and D2R in the nucleus accumbens, a central brain region for incentive processes, but not in dorsal striatum or prefrontal cortex. These findings highlight the impact of sucrose overconsumption during adolescence on DA system that may support deficits in reward-related disorders.
dc.language.isoENen_US
dc.subject.enAdolescence
dc.subject.enDopamine receptors
dc.subject.enNucleus accumbens
dc.subject.enProgressive ratio
dc.subject.enRat
dc.subject.enSucrose
dc.title.enProtracted motivational dopamine-related deficits following adolescence sugar overconsumption
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuropharm.2017.11.021en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalNeuropharmacologyen_US
bordeaux.page16-25en_US
bordeaux.volume129en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropharmacology&rft.date=2018&rft.volume=129&rft.spage=16-25&rft.epage=16-25&rft.eissn=0028-3908&rft.issn=0028-3908&rft.au=NANEIX,%20Fabien&DARLOT,%20Florence&DE%20SMEDT-PEYRUSSE,%20Veronique&PAPE,%20Jean-Remi&COUTUREAU,%20Etienne&rft.genre=article


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