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Tryptophan metabolic pathways are altered in obesity and are associated with systemic inflammation
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CUSSOTTO, Sofia | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DELGADO, Maria Ines | |
| dc.contributor.author | ANESI, Andrea | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DEXPERT, Sandra | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AUBERT, Agnes | |
| dc.contributor.author | BEAU, Cedric | |
| dc.contributor.author | FORESTIER, Damien | |
| dc.contributor.author | LEDAGUENEL, Patrick | |
| dc.contributor.author | MAGNE, Eric | |
| dc.contributor.author | MATTIVI, Fulvio | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile | |
| dc.date.accessioned | 2021-09-22T08:39:04Z | |
| dc.date.available | 2021-09-22T08:39:04Z | |
| dc.date.issued | 2020-04 | |
| dc.identifier.issn | 1664-3224 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112308 | |
| dc.description.abstractEn | Background: Obesity is a condition with a complex pathophysiology characterized by both chronic low-grade inflammation and changes in the gut microbial ecosystem. These alterations can affect the metabolism of tryptophan (TRP), an essential amino acid and precursor of serotonin (5-HT), kynurenine (KYN), and indoles. This study aimed to investigate alterations in KYN and microbiota-mediated indole routes of TRP metabolism in obese subjects relatively to non-obese controls and to determine their relationship with systemic inflammation. Methods: Eighty-five obese adults (avg. BMI = 40.48) and 42 non-obese control individuals (avg. BMI = 24.03) were recruited. Plasma levels of TRP catabolites were assessed using Ultra High Performance Liquid Chromatography-ElectroSpray-Ionization-Tandem Mass Spectrometry. High-sensitive C-reactive protein (hsCRP) and high-sensitive interleukin 6 (hsIL-6) were measured in the serum as markers of systemic inflammation using enzyme-linked immunosorbent assay. Results: Both KYN and microbiota-mediated indole routes of TRP metabolism were altered in obese subjects, as reflected in higher KYN/TRP ratio and lower 5-HT and indoles levels, relatively to non-obese controls. HsIL-6 and hsCRP were increased in obesity and were overall associated with TRP metabolic pathways alterations. Conclusion: These results indicate for the first time that KYN and indole TRP metabolic pathways are concomitantly altered in obese subjects and highlight their respective associations with obesity-related systemic inflammation. | |
| dc.description.sponsorship | A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition - ANR-15-HDHL-0001 | en_US |
| dc.description.sponsorship | Metabolic HEALTH through nutrition, microbiota and tryptophan bioMARKers - ANR-16-HDHL-0003 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Obesity | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Tryptophan | |
| dc.subject.en | Kynurenine | |
| dc.subject.en | Indoles | |
| dc.title.en | Tryptophan metabolic pathways are altered in obesity and are associated with systemic inflammation | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fimmu.2020.00557 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 32351500 | en_US |
| bordeaux.journal | Frontiers in Immunology | en_US |
| bordeaux.page | 1-7 | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Immunology&rft.date=2020-04&rft.volume=11&rft.spage=1-7&rft.epage=1-7&rft.eissn=1664-3224&rft.issn=1664-3224&rft.au=CUSSOTTO,%20Sofia&DELGADO,%20Maria%20Ines&ANESI,%20Andrea&DEXPERT,%20Sandra&AUBERT,%20Agnes&rft.genre=article |
