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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHUET, Lison
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELGADO, Maria Ines
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDEXPERT, Sandra
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSAUVANT, Julie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorBEAU, Cedric
dc.contributor.authorFORESTIER, Damien
dc.contributor.authorLEDAGUENEL, Patrick
dc.contributor.authorMAGNE, Eric
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
dc.date.accessioned2021-09-22T07:24:16Z
dc.date.available2021-09-22T07:24:16Z
dc.date.issued2021-05
dc.identifier.issn0889-1591en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112306
dc.description.abstractEnObjective : Neuropsychiatric symptoms are frequent in obese individuals. Mounting evidence suggests that adiposity-related inflammation contributes to this effect. This study assessed the relationship between adiposity, neuropsychiatric symptom dimensions and systemic inflammation in subjects stratified by body-mass-index (BMI). Methods : The study included 165 subjects, of whom 70 were very severely obese (BMI ≥ 40 kg/m2), 50 severely obese (BMI: 35–39.99 kg/m2), 21 overweight or moderately obese (BMI: 25–34.9 kg/m2), and 24 lean (BMI < 25 kg/m2). Depressive symptoms were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS) and the Mini-International Neuropsychiatric Interview (MINI). Fatigue and general neurobehavioral symptoms were assessed using the Multidimensional Fatigue Inventory (MFI) and Neurotoxicity Rating Scale (NRS) respectively. Serum levels of the inflammatory markers, high-sensitive (hs) CRP and hsIL-6, were determined by ELISA. Results : Severely obese subjects exhibited higher MADRS, MFI and NRS scores and were more frequently afflicted with current diagnosis of major depression than lean participants. Scores on psychometric scales were also increased in very severely obese subjects, although to a lesser extent. Alterations in neuropsychiatric dimensions were highly inter-related. HsCRP was significantly increased in subjects with severe or very severe obesity, while hsIL-6 was augmented in all obese groups. Overall, increased neuropsychiatric comorbidity was associated with greater systemic inflammation, notably hsCRP. Conclusion : Obesity is characterized by an increased prevalence of inter-related neuropsychiatric symptoms together with low-grade systemic inflammation augmenting with adiposity. The association between adiposity, systemic inflammation and neuropsychiatric alterations supports the contribution of adiposity-related inflammatory processes to neuropsychiatric comorbidities in obesity. These data suggest that consideration of adiposity characteristics may help identifying subjects at increased risk for neuropsychiatric comorbidity.
dc.description.sponsorshipRôle de l'Inflammation dans la Symptomatologie Neuropsychiatrique chez le Sujet Obèse - ANR-11-JSV1-0006en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enDepression
dc.subject.enInflammation
dc.subject.enNeuropsychiatric symptoms
dc.subject.enObesity
dc.subject.enPrevalence
dc.subject.enSemiology
dc.title.enRelationship between body mass index and neuropsychiatric symptoms: Evidence and inflammatory correlates
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbi.2021.02.031en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33684502en_US
bordeaux.journalBrain, Behavior, and Immunityen_US
bordeaux.page104-110en_US
bordeaux.volume94en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Brain,%20Behavior,%20and%20Immunity&amp;rft.date=2021-05&amp;rft.volume=94&amp;rft.spage=104-110&amp;rft.epage=104-110&amp;rft.eissn=0889-1591&amp;rft.issn=0889-1591&amp;rft.au=HUET,%20Lison&amp;DELGADO,%20Maria%20Ines&amp;DEXPERT,%20Sandra&amp;SAUVANT,%20Julie&amp;AOUIZERATE,%20Bruno&amp;rft.genre=article


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