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Omega-3 polyunsaturated fatty acids and brain aging
| dc.rights.license | open | en_US |
| dc.contributor.author | DENIS, Isabelle | |
| dc.contributor.author | POTIER, Brigitte | |
| dc.contributor.author | HEBERDEN, Christine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | VANCASSEL, Sylvie | |
| dc.date.accessioned | 2021-09-20T14:53:46Z | |
| dc.date.available | 2021-09-20T14:53:46Z | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 1363-1950 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112257 | |
| dc.description.abstractEn | The literature on the influence of dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) on brain aging has grown exponentially during the last decade. Many avenues have been explored but no global picture or clear evidence has emerged. Experimental studies have shown that ω-3 PUFA is involved in many neurobiological processes that are involved in neurotransmission and neuroprotection, indicating that these PUFAs may prevent age-related brain damage. Human studies have revealed only a weak link between ω-3 PUFA status and cognitive aging, whereas interventional studies have yet to confirm it. The purpose of this review is to analyze the developments in the area during the last 2 years.[br/] [br/] Human brain MRI studies have confirmed previous findings that ω-3 PUFA can protect the brain during aging; two intervention studies obtained clear evidence. We also analyzed the experimental data clarifying the involvement of ω-3 PUFA in neurotransmission, neuroprotection (including prevention of peroxidation, inflammation, and excitotoxicity), and neurogenesis, thereby helping the brain cope with aging.[br/] [br/] These recent human and experimental studies provide support for and clarification of how ω-3 PUFA protect against brain aging and highlight the main lines for future research. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | aging | |
| dc.subject.en | neurogenesis | |
| dc.subject.en | neuroprotection | |
| dc.subject.en | neurotransmission | |
| dc.subject.en | omega-3 polyunsaturated fatty acids | |
| dc.title.en | Omega-3 polyunsaturated fatty acids and brain aging | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/MCO.0000000000000141 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 25501348 | en_US |
| bordeaux.journal | Current Opinion in Clinical Nutrition and Metabolic Care | en_US |
| bordeaux.page | 139-146 | en_US |
| bordeaux.volume | 18 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Opinion%20in%20Clinical%20Nutrition%20and%20Metabolic%20Care&rft.date=2015&rft.volume=18&rft.issue=2&rft.spage=139-146&rft.epage=139-146&rft.eissn=1363-1950&rft.issn=1363-1950&rft.au=DENIS,%20Isabelle&POTIER,%20Brigitte&HEBERDEN,%20Christine&VANCASSEL,%20Sylvie&rft.genre=article |
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