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Docosahexaenoic acid (DHA) prevents corticosterone-induced changes in astrocyte morphology and function

dc.rights.licenseopenen_US
dc.contributor.authorCHAMPEIL POTOKAR, Gaelle
dc.contributor.authorHENNEBELLE, Marie
dc.contributor.authorLATOUR, Alizee
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorVANCASSEL, Sylvie
dc.contributor.authorDENIS, Isabelle
dc.date.accessioned2021-09-20T14:50:09Z
dc.date.available2021-09-20T14:50:09Z
dc.date.issued2016
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112256
dc.description.abstractEnThe many functions of astrocytes, such as glutamate recycling and morphological plasticity, enable them to stabilize synapses environment and protect neurons. Little is known about how they adapt to glucocorticoid-induced stress, and even less about the influence of dietary factors. We previously showed that omega-3 polyunsaturated fatty acids (3PUFA), dietary fats which alleviate stress responses, influence the way astroglia regulate glutamatergic synapses. We have explored the role of docosahexaenoic acid (DHA), the main 3PUFA, in the astroglial responses to corticosterone, the main stress hormone in rodents to determine whether 3PUFA help astrocytes resist stress. Cultured rat astrocytes were enriched in DHA or arachidonic acid (AA, the main 6PUFA) and given 100nM corticosterone for several days. Corticosterone stimulated astrocyte glutamate recycling by increasing glutamate uptake and glutamine synthetase (GS), and altered the astrocyte cytoskeleton. DHA-enriched astrocytes no longer responded to the action of corticosterone on glutamate uptake, had decreased GS, and the cytoskeletal effect of corticosterone was delayed, while AA-enriched cells were unaffected. The DHA-dependent anti-corticosterone effect was related to fewer glucocorticoid receptors, while corticosterone increased DHA incorporation into astrocyte membranes. Thus, DHA helps astrocytes resist the influence of corticosterone, so perhaps promoting a sustainable response by the stressed brain.
dc.description.sponsorshipAcides Gras Poly-Insaturés n-3 et prévention des dommages cérébraux liés au stress et au vieillissement : effets sur la synapse glutamatergique de l'hippocampe - ANR-09-ALIA-0006en_US
dc.language.isoENen_US
dc.subject.enastrocytes
dc.subject.endocosahexaenoic acid
dc.subject.englucocorticoids
dc.subject.enomega-3
dc.subject.enpolyunsaturated fatty acids
dc.subject.enstress
dc.title.enDocosahexaenoic acid (DHA) prevents corticosterone-induced changes in astrocyte morphology and function
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jnc.13510en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed26709611en_US
bordeaux.journalJournal of Neurochemistryen_US
bordeaux.page1155-1167en_US
bordeaux.volume136en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDUnileveren_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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