Impact of type 2 diabetes-associated mood disorders on the electrical properties of brain serotoninergic neurons
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MARTIN, Hugo | |
| dc.contributor.author | BULLICH, Sebastien | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DUCROCQ, Fabien | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TRIFILIEFF, Pierre | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.contributor.author | GUIARD, Bruno | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FIORAMONTI, Xavier | |
| dc.date.accessioned | 2021-09-20T10:18:19Z | |
| dc.date.available | 2021-09-20T10:18:19Z | |
| dc.date.issued | 2019-09 | |
| dc.date.conference | 2019-09-07 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112242 | |
| dc.description.abstractEn | Major Depressive Disorder (MDD) and Type-2 Diabetes (T2D) are diseases of major health concern. Recent epidemiological studies indicate that MDD is a comorbidity of T2D with serious detrimental health outcomes. Despite this, the mechanisms linking these two pathologies remain largely unknown. As the brain's serotoninergic (5-HT) system is involved in the pathophysiology of depression, we hypothesized that T2D can affect this network. Thus, we aimed to determine whether emotional behavior, serotoninergic neurotransmission and electric properties of 5-HT neurons are altered in a nutritional model of T2D-associated mood disorders, and if the insulin-sensitizing agent metformin can rescue these alterations. We assessed depressive-like and anxiety-like behavior in mice fed a high fat diet (HFD) for 16 weeks and treated for 4 weeks with metformin (300mg/kg; p.o) or vehicle control. The electrical activity of Dorsal Raphe Nucleus 5-HT neurons was assessed by patch clamp electrophysiology on brain slices from Pet1-cre-mcherry mice to specifically visualize 5-HT neurons. We observed depressive-like and anxiety-like behaviors in HFD-fed mice. Moreover, we observed that intrinsic properties of 5-HT neurons were altered by HFD feeding. In both cases, electrophysiological and behavioral alterations were reversed in part by the metformin treatment. In conclusion, these results show that HFD-induced mood disorders are associated with impaired 5-HT neuronal excitability. Interestingly, improving metabolic outcomes with the insulin-sensitizing agent metformin is sufficient to reduce emotional disorders and rescue 5-HT neuronal excitability, supporting the hypothesis that impairment in 5-HT neuronal activity in response to HFD-induced T2D is underlying associated mood disorders. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Impact of type 2 diabetes-associated mood disorders on the electrical properties of brain serotoninergic neurons | |
| dc.type | Communication dans un congrès avec actes | en_US |
| dc.identifier.doi | 10.1016/j.euroneuro.2019.09.050 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| bordeaux.page | S16-S17 | en_US |
| bordeaux.volume | 29 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | Supplement 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.conference.title | ECNP Congress | en_US |
| bordeaux.country | dk | en_US |
| bordeaux.title.proceeding | European Neuropsychopharmacology | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.conference.city | Copenhague | en_US |
| bordeaux.peerReviewed | oui | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2019-09&rft.volume=29&rft.issue=Supplement%206&rft.spage=S16-S17&rft.epage=S16-S17&rft.au=MARTIN,%20Hugo&BULLICH,%20Sebastien&DUCROCQ,%20Fabien&TRIFILIEFF,%20Pierre&LAYE,%20Sophie&rft.genre=proceeding |
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