Afficher la notice abrégée

Age-related impairment of declarative memory: linking memorization of temporal associations to GluN2B redistribution in dorsal CA1

dc.rights.licenseopenen_US
dc.contributor.authorAL ABED, Alice Shaam
dc.contributor.authorSELLAMI, Azza
dc.contributor.authorPOTIER-GEORGES, Mylene
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUCOURNEAU, Eva Gunnel
dc.contributor.authorGERBEAUD-LASSAU, Pauline
dc.contributor.authorBRAYDA-BRUNO, Laurent
dc.contributor.authorLAMOTHE, Valerie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSANS, Nathalie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDESMEDT, Aline
dc.contributor.authorVANHOUTTE, Peter
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBENNETAU, Catherine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTRIFILIEFF, Pierre
dc.contributor.authorMARIGHETTO, Aline
dc.date.accessioned2021-09-20T10:04:26Z
dc.date.available2021-09-20T10:04:26Z
dc.date.issued2020-10
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112240
dc.description.abstractEnGluN2B subunits of NMDA receptors have been proposed as a target for treating age‐related memory decline. They are indeed considered as crucial for hippocampal synaptic plasticity and hippocampus‐dependent memory formation, which are both altered in aging. Because a synaptic enrichment in GluN2B is associated with hippocampal LTP in vitro, a similar mechanism is expected to occur during memory formation. We show instead that a reduction of GluN2B synaptic localization induced by a single‐session learning in dorsal CA1 apical dendrites is predictive of efficient memorization of a temporal association. Furthermore, synaptic accumulation of GluN2B, rather than insufficient synaptic localization of these subunits, is causally involved in the age‐related impairment of memory. These challenging data identify extra‐synaptic redistribution of GluN2B‐containing NMDAR induced by learning as a molecular signature of memory formation and indicate that modulating GluN2B synaptic localization might represent a useful therapeutic strategy in cognitive aging.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enAge-related impairment of declarative memory: linking memorization of temporal associations to GluN2B redistribution in dorsal CA1
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/acel.13243en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33009891en_US
bordeaux.journalAging Cellen_US
bordeaux.pagee13243en_US
bordeaux.volume19en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDLabEx BRAINen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Aging%20Cell&rft.date=2020-10&rft.volume=19&rft.issue=10&rft.spage=e13243&rft.epage=e13243&rft.au=AL%20ABED,%20Alice%20Shaam&SELLAMI,%20Azza&POTIER-GEORGES,%20Mylene&DUCOURNEAU,%20Eva%20Gunnel&GERBEAUD-LASSAU,%20Pauline&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
NutriNeuro_AC_2020_Al Abed.pdf
Taille:
964.7Ko
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée