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Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations
| dc.rights.license | open | en_US |
| dc.contributor.author | ANDRIANARIVELO, Andry | |
| dc.contributor.author | SAINT-JOUR, Estefani | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | WALLE, Roman | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TRIFILIEFF, Pierre | |
| dc.contributor.author | VANHOUTTE, Peter | |
| dc.date.accessioned | 2021-09-06T08:38:27Z | |
| dc.date.available | 2021-09-06T08:38:27Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 1873-7064 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112090 | |
| dc.description.abstractEn | Drug addiction is a chronic and relapsing disorder that leads to compulsive drug intake despite deleterious consequences. By increasing dopamine (DA) in the mesolimbic system, drugs of abuse hijack the brain reward circuitry, which is critical for the development of enduring behavioral alterations. DA mainly acts onto DA D1 (D1R) and D2 (D2R) receptor subtypes, which are positively and negatively coupled to adenylyl cyclase, respectively. Extensive research has aimed at targeting these receptors for the treatment of addiction, however this often results in unwanted side-effects due to the implication of DA receptors in numerous physiological functions. A growing body of evidence indicates that the physical interaction of DA receptors with other receptors can finely tune their function, making DA receptor heteromers promising targets for more specific treatment strategies. An increasing number of articles highlighted the ability of both D1R and D2R to form heteromers, however, most studies carried out to date stem from observations in heterologous systems and the biological significance of DA receptor heteromers in vivo is only emerging. We focused this review on studies that were able to provide insights into functions on D1R and D2R heteromers in drug-evoked adaptations and discuss the limitations of current approaches to study receptor heteromers in vivo. This article is part of the Special Issue entitled 'Receptor heteromers and their allosteric receptor-receptor interactions'. | |
| dc.description.sponsorship | Rôle des heteromères formés par les récepteurs dopamine-glutamate et de signalisation dépendante du calcium nucléaire associée dans l'addiction - ANR-15-CE16-0017 | en_US |
| dc.description.sponsorship | Impact de la composition lipidique membranaire sur la transmission dopaminergique dépendante du récepteur D2 et la motivation - ANR-16-CE16-0022 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Addiction | |
| dc.subject.en | Dopamine | |
| dc.subject.en | Glutamate | |
| dc.subject.en | Receptor heteromers | |
| dc.subject.en | Signaling | |
| dc.subject.en | Striatum | |
| dc.title.en | Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.neuropharm.2018.12.003 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 30529032 | en_US |
| dc.description.sponsorshipEurope | Program Initiative d’Excellence | en_US |
| bordeaux.journal | Neuropharmacology | en_US |
| bordeaux.page | 42-50 | en_US |
| bordeaux.volume | 152 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Centre National de la Recherche Scientifique | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Sorbonne Université | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Fondation Jérôme Lejeune | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | École des Neurosciences Paris Île de France | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropharmacology&rft.date=2019&rft.volume=152&rft.spage=42-50&rft.epage=42-50&rft.eissn=1873-7064&rft.issn=1873-7064&rft.au=ANDRIANARIVELO,%20Andry&SAINT-JOUR,%20Estefani&WALLE,%20Roman&TRIFILIEFF,%20Pierre&VANHOUTTE,%20Peter&rft.genre=article |
