Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
| dc.rights.license | open | en_US |
| dc.contributor.author | MADORE, Charlotte | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LEYROLLE, Quentin | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LACABANNE, Chloe | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | BENMAMAR-BADEL, Anouk | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JOFFRE, Corinne | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | NADJAR, Agnes | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.date.accessioned | 2021-09-03T14:36:41Z | |
| dc.date.available | 2021-09-03T14:36:41Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1687-5443 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112083 | |
| dc.description.abstractEn | Several genetic causes of autism spectrum disorder (ASD) have been identified. However, more recent work has highlighted that certain environmental exposures early in life may also account for some cases of autism. Environmental insults during pregnancy, such as infection or malnutrition, seem to dramatically impact brain development. Maternal viral or bacterial infections have been characterized as disruptors of brain shaping, even if their underlying mechanisms are not yet fully understood. Poor nutritional diversity, as well as nutrient deficiency, is strongly associated with neurodevelopmental disorders in children. For instance, imbalanced levels of essential fatty acids, and especially polyunsaturated fatty acids (PUFAs), are observed in patients with ASD and other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder (ADHD) and schizophrenia). Interestingly, PUFAs, and specifically n-3 PUFAs, are powerful immunomodulators that exert anti-inflammatory properties. These prenatal dietary and immunologic factors not only impact the fetal brain, but also affect the microbiota. Recent work suggests that the microbiota could be the missing link between environmental insults in prenatal life and future neurodevelopmental disorders. As both nutrition and inflammation can massively affect the microbiota, we discuss here how understanding the crosstalk between these three actors could provide a promising framework to better elucidate ASD etiology. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Animals | |
| dc.subject.en | Attention Deficit Disorder with Hyperactivity | |
| dc.subject.en | Autism Spectrum Disorder | |
| dc.subject.en | Autistic Disorder | |
| dc.subject.en | Child Development Disorders | |
| dc.subject.en | Pervasive | |
| dc.subject.en | Fatty Acids | |
| dc.subject.en | Omega-3 | |
| dc.subject.en | Humans | |
| dc.subject.en | Microbiota | |
| dc.subject.en | Nutritional Status | |
| dc.title.en | Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1155/2016/3597209 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 27840741 | en_US |
| dc.description.sponsorshipEurope | Program Initiative d’Excellence | en_US |
| bordeaux.journal | Neural plasticity | en_US |
| bordeaux.page | 3597209 | en_US |
| bordeaux.volume | 2016 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional, Île-de-France | en_US |
| bordeaux.identifier.funderID | Cerebral Palsy Foundation | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neural%20plasticity&rft.date=2016&rft.volume=2016&rft.spage=3597209&rft.epage=3597209&rft.eissn=1687-5443&rft.issn=1687-5443&rft.au=MADORE,%20Charlotte&LEYROLLE,%20Quentin&LACABANNE,%20Chloe&BENMAMAR-BADEL,%20Anouk&JOFFRE,%20Corinne&rft.genre=article |
