Role of Adiposity-Driven Inflammation in Depressive Morbidity
dc.rights.license | open | en_US |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LASSELIN, Julie | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | CASTANON, Nathalie | |
dc.date.accessioned | 2021-09-01T09:04:11Z | |
dc.date.available | 2021-09-01T09:04:11Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1740-634X | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110275 | |
dc.description.abstractEn | Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies. | |
dc.description.sponsorship | Rôle de l'Inflammation dans la Symptomatologie Neuropsychiatrique chez le Sujet Obèse - ANR-11-JSV1-0006 | en_US |
dc.language.iso | EN | en_US |
dc.subject.en | Depressive Disorder | |
dc.subject.en | Humans | |
dc.subject.en | Inflammation | |
dc.subject.en | Overweight | |
dc.title.en | Role of Adiposity-Driven Inflammation in Depressive Morbidity | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/npp.2016.123 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 27402495 | en_US |
bordeaux.journal | Neuropsychopharmacology | en_US |
bordeaux.page | 115-128 | en_US |
bordeaux.volume | 42 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 1 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
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