High sensitivity C reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome
| dc.rights.license | open | en_US |
| dc.contributor.author | LAFITTE, Marianne | |
| dc.contributor.author | TASTET, Sandrine | |
| dc.contributor.author | PEREZ, Paul | |
| dc.contributor.author | SERISE, Marie-Aimee | |
| dc.contributor.author | GRANDOULIER, Anne-Sophie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AOUIZERATE, Bruno
IDREF: 069471851 | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | SIBON, Igor | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | COUFFINHAL, Thierry | |
| dc.date.accessioned | 2021-09-01T08:49:34Z | |
| dc.date.available | 2021-09-01T08:49:34Z | |
| dc.date.issued | 2015-03-18 | |
| dc.identifier.issn | 1471-2261 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110273 | |
| dc.description.abstractEn | BACKGROUND: Major depression disorder (MDD) is a common condition in patients suffering from acute coronary syndrome (ACS), and depression is a risk factor for mortality following an ACS. Growing evidence suggests that there is an intricate interplay between atherosclerosis, inflammation and depression. The aim of this study was to investigate the role of atherosclerosis-induced inflammation in the mediation of MDD. METHODS: 87 patients without depression were recruited at the time of an ACS, evaluated at 3 and 7 days and followed at 1, 3 and 9 months for the occurrence of a MDD as assessed by structured interviews (MINI). At each time point, they were monitored for inflammatory markers (high sensitivity C Reactive Protein {hsCRP} and fibrinogen), cardiovascular risk factors and atherosclerosis burden. Association between possible predictive characteristics and depression was assessed using a multivariable logistic regression model. RESULTS: The overall incidence of MDD, in this population, was 28.7% [95% CI: 19.5 - 39.4] during the 9-month follow up period. Elevated hsCRP was not associated with depression onset after an ACS (adjusted OR: 1.07 [0.77 - 1.48]; p = 0.70), and similarly no association was found with fibrinogen. Furthermore, we found no association between hsCRP, fibrinogen or atherosclerosis burden at any time-point, and the occurrence of a MDD (or HDRS-17 and MADRS). The only factor associated with depression occurrence after an ACS was a previous personal history of depression (adjusted OR: 11.02 [2.74 to 44.34]; p = 0.0007). CONCLUSIONS: The present study shows that after an ACS, patients treated with optimal medications could have a MDD independent of elevated hsCRP or fibrinogen levels. Personal history of depression may be a good marker to select patients who should be screened for depression after an ACS. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Acute Coronary Syndrome | |
| dc.subject.en | Adult | |
| dc.subject.en | Aged | |
| dc.subject.en | Biomarkers | |
| dc.subject.en | C-Reactive Protein | |
| dc.subject.en | Coronary Artery Disease | |
| dc.subject.en | Depressive Disorder | |
| dc.subject.en | Major | |
| dc.subject.en | Female | |
| dc.subject.en | Fibrinogen | |
| dc.subject.en | Humans | |
| dc.subject.en | Male | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Prognosis | |
| dc.subject.en | Risk Factors | |
| dc.title.en | High sensitivity C reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1186/s12872-015-0015-3 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 25888123 | en_US |
| bordeaux.journal | BMC Cardiovascular Disorders | en_US |
| bordeaux.page | 23 | en_US |
| bordeaux.volume | 15 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | INSERM | |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Cardiovascular%20Disorders&rft.date=2015-03-18&rft.volume=15&rft.spage=23&rft.epage=23&rft.eissn=1471-2261&rft.issn=1471-2261&rft.au=LAFITTE,%20Marianne&TASTET,%20Sandrine&PEREZ,%20Paul&SERISE,%20Marie-Aimee&GRANDOULIER,%20Anne-Sophie&rft.genre=article |
