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Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorREY, Charlotte
dc.contributor.authorDELPECH, Jean-Christophe
dc.contributor.authorMADORE, Charlotte
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorNADJAR, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGREENHALGH, Andrew D.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAMADIEU, Camille
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPALLET, Veronique
ORCID: 0000-0002-9078-3269
IDREF: 066841763
dc.contributor.authorVAYSSE, Carole
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
dc.date.accessioned2021-08-31T09:53:18Z
dc.date.available2021-08-31T09:53:18Z
dc.date.issued2019
dc.identifier.issn1090-2139en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110264
dc.description.abstractEnThe brain is highly enriched in long chain polyunsaturated fatty acids (LC-PUFAs) that display immunomodulatory properties in the brain. At the periphery, the modulation of inflammation by LC-PUFAs occurs through lipid mediators called oxylipins which have anti-inflammatory and pro-resolving activities when derived from n-3 LC-PUFAs and pro-inflammatory activities when derived from n-6 LC-PUFAs. However, whether a diet rich in LC-PUFAs modulates oxylipins and neuroinflammation in the brain has been poorly investigated. In this study, the effect of a dietary n-3 LC-PUFA supplementation on oxylipin profile and neuroinflammation in the brain was analyzed. Mice were given diets deficient or supplemented in n-3 LC-PUFAs for a 2-month period starting at post-natal day 21, followed by a peripheral administration of lipopolysaccharide (LPS) at adulthood. We first showed that dietary n-3 LC-PUFA supplementation induced n-3 LC-PUFA enrichment in the hippocampus and subsequently an increase in n-3 PUFA-derived oxylipins and a decrease in n-6 PUFA-derived oxylipins. In response to LPS, n-3 LC-PUFA deficient mice presented a pro-inflammatory oxylipin profile whereas n-3 LC-PUFA supplemented mice displayed an anti-inflammatory oxylipin profile in the hippocampus. Accordingly, the expression of cyclooxygenase-2 and 5-lipoxygenase, the enzymes implicated in pro- and anti-inflammatory oxylipin synthesis, was induced by LPS in both diets. In addition, LPS-induced pro-inflammatory cytokine increase was reduced by dietary n-3 LC-PUFA supplementation. These results indicate that brain n-3 LC-PUFAs increase by dietary means and promote the synthesis of anti-inflammatory derived bioactive oxylipins. As neuroinflammation plays a key role in all brain injuries and many neurodegenerative disorders, the present data suggest that dietary habits may be an important regulator of brain cytokine production in these contexts.
dc.language.isoENen_US
dc.subjectOmega-3 Fatty Acids
dc.subjectOmega-6 Fatty Acids
dc.subject.en18-HEPE
dc.subject.enAnimals
dc.subject.enBrain
dc.subject.enCytokines
dc.subject.enDHA
dc.subject.enDiet
dc.subject.enDietary Supplements
dc.subject.enEET
dc.subject.enEPA
dc.subject.enFatty Acids
dc.subject.enUnsaturated
dc.subject.enHippocampus
dc.subject.enInflammation
dc.subject.enLipopolysaccharides
dc.subject.enMale
dc.subject.enMice
dc.subject.enInbred C57BL
dc.subject.enModels
dc.subject.enAnimal
dc.subject.enN-3 PUFA
dc.subject.enNeuroinflammation
dc.subject.enOxylipin
dc.subject.enOxylipins
dc.subject.enTxB2
dc.title.enDietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbi.2018.07.025en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed30086401en_US
bordeaux.journalBrain, Behavior, and Immunityen_US
bordeaux.page17-27en_US
bordeaux.volume76en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDAssociation Nationale de la Recherche et de la Technologieen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDSociété Française de Nutritionen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior,%20and%20Immunity&rft.date=2019&rft.volume=76&rft.spage=17-27&rft.epage=17-27&rft.eissn=1090-2139&rft.issn=1090-2139&rft.au=REY,%20Charlotte&DELPECH,%20Jean-Christophe&MADORE,%20Charlotte&NADJAR,%20Agnes&GREENHALGH,%20Andrew%20D.&rft.genre=article


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