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Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
dc.rights.license | open | en_US |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | REY, Charlotte | |
dc.contributor.author | DELPECH, Jean-Christophe | |
dc.contributor.author | MADORE, Charlotte | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | NADJAR, Agnes | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | GREENHALGH, Andrew D. | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | AMADIEU, Camille | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | AUBERT, Agnes | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | PALLET, Veronique
ORCID: 0000-0002-9078-3269 IDREF: 066841763 | |
dc.contributor.author | VAYSSE, Carole | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | JOFFRE, Corinne | |
dc.date.accessioned | 2021-08-31T09:53:18Z | |
dc.date.available | 2021-08-31T09:53:18Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1090-2139 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110264 | |
dc.description.abstractEn | The brain is highly enriched in long chain polyunsaturated fatty acids (LC-PUFAs) that display immunomodulatory properties in the brain. At the periphery, the modulation of inflammation by LC-PUFAs occurs through lipid mediators called oxylipins which have anti-inflammatory and pro-resolving activities when derived from n-3 LC-PUFAs and pro-inflammatory activities when derived from n-6 LC-PUFAs. However, whether a diet rich in LC-PUFAs modulates oxylipins and neuroinflammation in the brain has been poorly investigated. In this study, the effect of a dietary n-3 LC-PUFA supplementation on oxylipin profile and neuroinflammation in the brain was analyzed. Mice were given diets deficient or supplemented in n-3 LC-PUFAs for a 2-month period starting at post-natal day 21, followed by a peripheral administration of lipopolysaccharide (LPS) at adulthood. We first showed that dietary n-3 LC-PUFA supplementation induced n-3 LC-PUFA enrichment in the hippocampus and subsequently an increase in n-3 PUFA-derived oxylipins and a decrease in n-6 PUFA-derived oxylipins. In response to LPS, n-3 LC-PUFA deficient mice presented a pro-inflammatory oxylipin profile whereas n-3 LC-PUFA supplemented mice displayed an anti-inflammatory oxylipin profile in the hippocampus. Accordingly, the expression of cyclooxygenase-2 and 5-lipoxygenase, the enzymes implicated in pro- and anti-inflammatory oxylipin synthesis, was induced by LPS in both diets. In addition, LPS-induced pro-inflammatory cytokine increase was reduced by dietary n-3 LC-PUFA supplementation. These results indicate that brain n-3 LC-PUFAs increase by dietary means and promote the synthesis of anti-inflammatory derived bioactive oxylipins. As neuroinflammation plays a key role in all brain injuries and many neurodegenerative disorders, the present data suggest that dietary habits may be an important regulator of brain cytokine production in these contexts. | |
dc.language.iso | EN | en_US |
dc.subject | Omega-3 Fatty Acids | |
dc.subject | Omega-6 Fatty Acids | |
dc.subject.en | 18-HEPE | |
dc.subject.en | Animals | |
dc.subject.en | Brain | |
dc.subject.en | Cytokines | |
dc.subject.en | DHA | |
dc.subject.en | Diet | |
dc.subject.en | Dietary Supplements | |
dc.subject.en | EET | |
dc.subject.en | EPA | |
dc.subject.en | Fatty Acids | |
dc.subject.en | Unsaturated | |
dc.subject.en | Hippocampus | |
dc.subject.en | Inflammation | |
dc.subject.en | Lipopolysaccharides | |
dc.subject.en | Male | |
dc.subject.en | Mice | |
dc.subject.en | Inbred C57BL | |
dc.subject.en | Models | |
dc.subject.en | Animal | |
dc.subject.en | N-3 PUFA | |
dc.subject.en | Neuroinflammation | |
dc.subject.en | Oxylipin | |
dc.subject.en | Oxylipins | |
dc.subject.en | TxB2 | |
dc.title.en | Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.bbi.2018.07.025 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 30086401 | en_US |
bordeaux.journal | Brain, Behavior, and Immunity | en_US |
bordeaux.page | 17-27 | en_US |
bordeaux.volume | 76 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
bordeaux.identifier.funderID | Association Nationale de la Recherche et de la Technologie | en_US |
bordeaux.identifier.funderID | Université de Bordeaux | en_US |
bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Société Française de Nutrition | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior,%20and%20Immunity&rft.date=2019&rft.volume=76&rft.spage=17-27&rft.epage=17-27&rft.eissn=1090-2139&rft.issn=1090-2139&rft.au=REY,%20Charlotte&DELPECH,%20Jean-Christophe&MADORE,%20Charlotte&NADJAR,%20Agnes&GREENHALGH,%20Andrew%20D.&rft.genre=article |
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